4408-64-4 Usage
Description
N-Methyliminodiacetic acid, also known as MIDA, is an organic compound that is a white to light yellow crystal powder. It is characterized by its chemical properties and is widely used in various applications due to its unique reactivity and ability to form complexes.
Uses
Used in Chemical Synthesis:
N-Methyliminodiacetic acid is used as a reagent for the preparation of bis-(1H-benzoimidazol-2-ylmethyl)-methyl-amine by condensation with benzene-1,2-diamine. This application is crucial in the synthesis of various organic compounds and pharmaceuticals.
Used in Cross-Coupling Reactions:
In the field of organic chemistry, N-Methyliminodiacetic acid is utilized in Suzuki cross-coupling reactions with MIDA boronates. This process is essential for the formation of carbon-carbon bonds, which are vital in the synthesis of complex organic molecules and pharmaceuticals.
Used as a Protecting Group for Boronic Acids:
N-Methyliminodiacetic acid serves as a protecting group for boronic acids, which are important intermediates in organic synthesis. The protection of boronic acids with MIDA allows for selective reactions and prevents unwanted side reactions, thus improving the overall yield and purity of the target compounds.
Used as a Chelating Agent for Metals:
N-Methyliminodiacetic acid is used as a chelating agent for various metals. Its ability to form stable complexes with metal ions makes it a valuable tool in various industries, including the pharmaceutical, chemical, and environmental sectors. Chelating agents are essential for stabilizing metal ions, preventing metal-catalyzed reactions, and facilitating the separation and purification of metal-containing compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 4408-64-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,4,0 and 8 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 4408-64:
(6*4)+(5*4)+(4*0)+(3*8)+(2*6)+(1*4)=84
84 % 10 = 4
So 4408-64-4 is a valid CAS Registry Number.
InChI:InChI=1/C5H9NO4/c1-6(2-4(7)8)3-5(9)10/h2-3H2,1H3,(H,7,8)(H,9,10)/p-1
4408-64-4Relevant articles and documents
Multicomponent mapping of boron chemotypes furnishes selective enzyme inhibitors
Tan, Joanne,Iii, Armand B. Cognetta,Diaz, Diego B.,Lum, Kenneth M.,Adachi, Shinya,Kundu, Soumajit,Cravatt, Benjamin F.,Yudin, Andrei K.
, (2017)
Heteroatom-rich organoboron compounds have attracted attention as modulators of enzyme function. Driven by the unmet need to develop chemoselective access to boron chemotypes, we report herein the synthesis of α-and β-aminocyano(MIDA)boronates from borylated carbonyl compounds. Activity-based protein profiling of the resulting β-aminoboronic acids furnishes selective and cell-active inhibitors of the (ox)lipid-metabolizing enzyme α/β-hydrolase domain 3 (ABHD3). The most potent compound displays nanomolar in vitro and in situ IC50 values and fully inhibits ABHD3 activity in human cells with no detectable cross-reactivity against other serine hydrolases. These findings demonstrate that synthetic methods that enhance the heteroatom diversity of boron-containing molecules within a limited set of scaffolds accelerate the discovery of chemical probes of human enzymes.
NOVEL BORONIC ESTERS AND METHODS FOR MAKING THE SAME
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Paragraph 0133, (2020/12/20)
There is provide herein a compound of Formula (1): wherein R1, R2, R3, R4, and R5 are each independently H or an organic group.
Fe-Catalyzed Reductive Couplings of Terminal (Hetero)Aryl Alkenes and Alkyl Halides under Aqueous Micellar Conditions
Pang, Haobo,Wang, Ye,Gallou, Fabrice,Lipshutz, Bruce H.
supporting information, p. 17117 - 17124 (2019/11/03)
The combination of a vinyl-substituted aromatic or heteroaromatic and an alkyl bromide or iodide leads, in the presence of Zn and a catalytic amount of an Fe(II) salt, to a net reductive coupling. The new C-C bond is regiospecifically formed at rt at the β-site of the alkene. The coupling only occurs in an aqueous micellar medium, where a radical process is likely, supported by several control experiments. A mechanism based on these data is proposed.
