4421-48-1

Basic information

• Product Name: Cyanamide, cyclohexyl-
• Synonyms: N-Cyclohexyl-cyanamid;Cyclohexylcyanamid;cyclohexyl cyanamide;Cyclohexyl-carbamonitril
• CAS NO: 4421-48-1
• Molecular Formula: C7H12N2
• Molecular Weight: 124.186
• Mol File: 4421-48-1.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: Cyanamide, cyclohexyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyanamide, cyclohexyl-(4421-48-1)
• EPA Substance Registry System: Cyanamide, cyclohexyl-(4421-48-1)

Safety Data

• Hazardous Substances Data: 4421-48-1(Hazardous Substances Data)

Upstream product

• 18102-76-6 tetrazol-1-yl-cyclohexane 
• 108-91-8 cyclohexylamine 
• 1122-82-3 isothiocyanatocyclohexane 
• 3173-53-3 Cyclohexyl isocyanate 
• 859214-49-6 2-cyano-4-chloro-5-methoxypyridazin-3(2H)-one 
• 859214-48-5 2-cyano-4,5-dichloropyridazin-3(2H)-one 
• 931-53-3 Cyclohexyl isocyanide 
• 143-33-9 sodium cyanide 
• 5055-72-1 N-cyclohexylthiourea 

Downstream Products

• 14910-05-5 cyclohexyl-(1⁽²⁾H-tetrazol-5-yl)-amine 
• 66907-76-4 1-(cyclohexyl)-1H-tetrazol-5-amine 
• 25855-23-6 cyclohexylphenylcyanamide 
• 724-92-5 N-cicloesil-α-ossofenilacetamide 
• 1631985-05-1 N-cyano-N-cyclohexyl-2-naphthamide 
• 1414382-22-1 1-cyclohexyl 2-iminohydantoin 
• 54088-56-1 1-(tert-butyl)-3-cyclohexylurea 
• 1034186-46-3 methyl N-cyano-N-cyclohexylaminoacetate 
• 68259-89-2 6-cyclohexyl-9-(4-methyl-piperazin-1-ylmethyl)-1,4-dioxa-6,9-diaza-spiro[4.4]nonane-7,8-dione 
• 68259-88-1 6-cyclohexyl-9-morpholin-4-ylmethyl-1,4-dioxa-6,9-diaza-spiro[4.4]nonane-7,8-dione 
• 698-90-8 N'-cyclohexylurea 
• 124190-34-7 N-cyclohexyl-N'-(2-methylphenyl)guanidine 
• 89026-67-5 Tris (N-cyan-N-cyclohexyl-amino)-methan 
• 68259-92-7 1-cyclohexyl-2-morpholin-4-yl-1H-imidazole-4,5-dione 

Relevant articles and documents

Iron-mediated desulphurization approach: synthesis of cyanamides and their conversions

The iron-mediated efficient multi-component method has been demonstrated for the synthesis of substituted cyanamides from isothiocyanates under mild reaction conditions. Subsequent nucleophilic addition and desulfurization are involved in this proposed synthetic methodology. All the reactions are rapid, facile, and accomplished at room temperature. A variety of substrates readily underwent the optimized reaction conditions to provide their respective target products in good to excellent yields. Furthermore, we have confirmed that no other by-products could be identified during our experimental reaction process. Graphical abstract: Iron-mediated efficient multi-component method has been demonstrated for the synthesis of substituted cyanamides from isothiocyanates under mild reaction conditions. Subsequent nucleophilic addition and desulfurization are involved in this proposed synthetic methodology.[Figure not available: see fulltext.].

One-pot three-component tandem reaction: Synthesis of aryl/alkyl cyanamides libraries and their further conversion into tetrazole derivatives

We have developed methodology for the synthesis of aryl/alkyl cyanamides from amines in one-pot four steps reaction using cheap, readily available and air stable copper source as catalyst under mild reaction conditions. We have also studied the application of cyanamides. In this connection, we could construct aryl tetrazolamine from cyanamides using click reaction.

Selective Gold-Catalysed Synthesis of Cyanamides and 1-Substituted 1H-Tetrazol-5-Amines from Isocyanides

The newly discovered gold-catalysed reaction of isocyanides with hydrazoic acid generated in situ from trimethylsilyl azide and methanol (or, alternatively, from NaN3/AcOH) produces either cyanamides or 1-substituted 1H-tetrazol-5-amines, depending on the amount of available HN3. The reaction proceeds selectively and in generally high yields of either product, thus providing a particularly convenient access to a wide range of substituted 1H-tetrazol-5-amines that are rather difficult to access otherwise.