4430-97-1Relevant articles and documents
CHROMATOGRAPHIC AND SPECTROSCOPIC INVESTIGATION OF THE PRODUCTS OF OXIDATION OF TYROSINE WITH OZONE.
Ignatenko,Cherenkevich,Komyak
, p. 798 - 802 (1984)
It has been shown that ozone in low concentrations readily oxidizes aromatic amino acids both in solution and when constituents of proteins resulting in the formation of a whole series of oxidation products. Since the oxidation products are physiologically active it was of interest to study them further. In the present work the main molecular products obtained by oxidation of tyrosine with ozone are established, and possible mechanisms of their formation discussed.
Biochemical characterization of two differentially expressed polyphenol oxidases from hybrid poplar
Wang, Jiehua,Constabel, C. Peter
, p. 115 - 121 (2003)
Two polyphenol oxidase isoforms with distinct expression patterns were identified in hybrid poplar (Populus trichocarpax P. deltoides). PPO-1, corresponding to the previously cloned PtdPPO (Constabel et al., Plant Physiol. 124: 285-295) was primarily leaf
SKIN-WHITENING COSMETIC COMPOSITION COMPRISING LACTOBACILLUS RHAMNOSUS LM1011 HAVING IMMUNOSTIMULATING ACTIVITY
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Paragraph 0009, (2020/05/13)
The present invention relates to a cosmetic composition for skin whitening comprising novel Lactobacillus rhamnosus LM1011 as an active ingredient. More specifically, the present invention provides a cosmetic composition for skin whitening, comprising novel Lactobacillus rhamnosus LM1011 as an active ingredient, and reducing melanin production by regulating tyrosinase activity.(AA) L-tyrosine 4-hydroxy-1-phenylalanine(BB) Tyrosinase(CC) L-dopa 1-3,4-dihydroxyphenylalanine(DD) Dehydroascorbic acid(EE) Ascorbic acid(FF) Tyrosinase(GG) Dopaquinone(HH) MelaninCOPYRIGHT KIPO 2020
Coumaric acid derivatives as tyrosinase inhibitors: Efficacy studies through in silico, in vitro and ex vivo approaches
Fernandes, Jo?o Paulo S.,Ferrarini, Márcio,Mercaldi, Vitória Gallo,Nazato, Lucas Idacir Sbrugnera,Padovani, Giovana,Sufi, Bianca da Silva,Varela, Marina Themoteo
, (2020/08/06)
p-Coumaric acid is a known inhibitor of tyrosinase, an enzyme involved in the initial steps of the melanin synthesis in human and other species. However, its low lipophilicity impairs its penetration through skin and efficacy as antimelanogenic agent indeed. Accordingly, this paper reports the assessment of several coumaric acid derivatives as tyrosinase inhibitors and antimelanogenic agents in in vitro, in silico and ex vivo assays. The compounds were designed with modifications in the aromatic and acid moieties of p-coumaric acid, being the coumarate esters the most promising derivatives. The compounds showed higher tyrosinase inhibitory activity (pIC50 3.7–4.2) than the parent acid, being compounds 1d, 1e and 1f the most potent inhibitors. Docking analysis showed that these esters are competitive inhibitors per se, and act independently of a redox mechanism as suggested by DPPH assays. Moreover, the esters showed efficacy in reducing the melanin deposition in human skin fragments at 0.1% concentration, especially compound 1e. In summary, there is an important equilibria between tyrosinase affinity and lipophilicity that must be considered to get effective antimelanogenic agents with adequate permeability in the skin.