63-84-3 Usage
Description
DL-DOPA, also known as 3,4-Dihydroxy-DL-phenylalanine, is a naturally occurring amino acid that serves as a precursor to the neurotransmitter dopamine. It is an essential compound in the biosynthesis of melanin, a pigment found in various tissues and organs. DL-DOPA is characterized by its unique structure, featuring two hydroxyl groups attached to a phenylalanine backbone, which contributes to its diverse applications across different industries.
Uses
Used in Pharmaceutical Industry:
DL-DOPA is used as a dopamine precursor for the treatment of Parkinson's disease and other movement disorders. It helps increase dopamine levels in the brain, improving motor function and reducing symptoms associated with these conditions.
Used in Organic Synthesis:
DL-DOPA is utilized as a key intermediate in the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and other specialty chemicals. Its unique structure and reactivity make it a valuable building block for the development of new molecules with potential applications in various fields.
Used in Cosmetics Industry:
In the cosmetics industry, DL-DOPA is used as a skin-lightening agent due to its ability to inhibit melanin production. It is incorporated into skincare products to help reduce the appearance of age spots, hyperpigmentation, and other skin discolorations.
Used in Food Industry:
DL-DOPA is also used in the food industry as a natural colorant and flavor enhancer. Its ability to mimic the taste and color of certain foods makes it a popular choice for manufacturers seeking to improve the sensory properties of their products without using synthetic additives.
Synthesis Reference(s)
Journal of the American Chemical Society, 70, p. 693, 1948 DOI: 10.1021/ja01182a079
Biochem/physiol Actions
3,4-dihydroxyphenylalanine is an immediate precursor of dopamine, which is a product of tyrosine hydroxylase.
Check Digit Verification of cas no
The CAS Registry Mumber 63-84-3 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 6 and 3 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 63-84:
(4*6)+(3*3)+(2*8)+(1*4)=53
53 % 10 = 3
So 63-84-3 is a valid CAS Registry Number.
InChI:InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)
63-84-3Relevant articles and documents
Barry et al.
, p. 693 (1948)
Biocascade Synthesis of L-Tyrosine Derivatives by Coupling a Thermophilic Tyrosine Phenol-Lyase and L-Lactate Oxidase
Jiang, Yiqi,Ju, Shuyun,Li, Guosi,Lian, Jiazhang,Lin, Jianping,Wu, Mianbin,Xue, Hailong,Yang, Lirong
supporting information, (2020/02/25)
A one-pot biocascade of two enzymatic steps catalyzed by an l-lactate oxidase and a tyrosine phenol-lyase has been successfully developed in the present study. The reaction provides an efficient method for the synthesis of l-tyrosine derivatives, which exhibits readily available starting materials and excellent yields. In the first step, an in situ generation of pyruvate from readily available bio-based l-lactate catalyzed by a highly active l-lactate oxidase from Aerococcus viridans (AvLOX) was developed (using oxygen as oxidant and catalase as hydrogen peroxide removing reagent). Pyruvate thus produced underwent C–C coupling with phenol derivatives as acceptor substrate using specially designed thermophilic tyrosine phenol-lyase mutants from Symbiobacterium toebii (TTPL). Overall, this cascade avoids the high cost and easy decomposition of pyruvate and offered an efficient and environmentally friendly procedure for l-tyrosine derivatives synthesis.
FUNCTIONALIZED FLUORINE CONTAINING PHTHALOCYANINE MOLECULES
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, (2015/03/16)
Functionalized fluorine containing phthalocyanine molecules, methods of making, and methods of use in diagnostic applications and disease treatment are disclosed herein. In some embodiments, the fluorine containing phthalocyanine molecules are functionalized with a reactive functional group or at least one cancer-targeting ligand (CTL). The CTL can facilitate more efficient binding and/or internalization to a cancer cell than to a healthy cell. The CTL can inhibit expression of oncoprotein in some embodiments. The pthalocyanine moiety can be used in diagnostic applications, such as fluorescence labeling of a cancer cell, and/or treatment applications, such as catalyzing formation of a reactive oxygen species (ROS) which can contribute to cell death of a cancer cell.
