4431-00-9 Usage
Description
Aurintricarboxylic acid, also known as ATA, is a member of the quinomethanes class and is characterized by its deep red coarse crystalline powder appearance. It is a 3-methylidene-6-oxocyclohexa-1,4-diene-1-carboxylic acid with 4-carboxy-3-hydroxyphenyl groups replacing the methylidene hydrogens. The trisodium salt of this compound is known as the biological stain 'chrome violet CG,' while the triammonium salt is referred to as 'aluminon.'
Uses
Used in Pharmaceutical Applications:
Aurintricarboxylic acid is used as an endonuclease inhibitor, apoptosis inhibitor, and topoisomerase II inhibitor for its ability to inhibit cellular processes that are dependent on the formation of protein-nucleic acid complexes. It plays a crucial role in various research and therapeutic applications.
Used in Angiogenesis Inhibition:
Aurintricarboxylic acid is used as an inhibitor to reduce the angiogenic activity of fibroblast growth factor (FGF). By binding to FGF, it helps in controlling the formation of new blood vessels, which can be beneficial in the treatment of certain diseases and conditions.
Used in Cellular Research:
Aurintricarboxylic acid is employed as a tool in cellular research to study the effects of apoptotic cell death in various cell types induced by different factors. Its ability to inhibit protein-nucleic acid interactions makes it a valuable compound for understanding cellular processes and developing potential therapeutic strategies.
Used in Signal Transduction:
Aurintricarboxylic acid is used as a stimulator of the tyrosine phosphorylation of MAP kinases, which are essential components of signal transduction pathways in cells. This application helps researchers investigate the role of these kinases in cellular signaling and response to various stimuli.
Purification Methods
The acid is dissolved in aqueous NaOH, NaHSO3 solution is added until the colour is discharged and then the tricarboxylic acid is precipitated with HCl. [Heisig & Lauer Org Synth Coll Vol I 54 1941, Beilstein 10 IV 4161]. Do not extract the acid with hot water because it softens, forming a viscous mass. Make a solution in aqueous NH3. Aluminon is the NH4 salt.
Check Digit Verification of cas no
The CAS Registry Mumber 4431-00-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,4,3 and 1 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 4431-00:
(6*4)+(5*4)+(4*3)+(3*1)+(2*0)+(1*0)=59
59 % 10 = 9
So 4431-00-9 is a valid CAS Registry Number.
InChI:InChI=1/C22H14O9/c23-16-4-1-10(7-13(16)20(26)27)19(11-2-5-17(24)14(8-11)21(28)29)12-3-6-18(25)15(9-12)22(30)31/h1-9,23-24H,(H,26,27)(H,28,29)(H,30,31)
4431-00-9Relevant articles and documents
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Holaday
, p. 989 (1940)
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Scherrer,Smith
, p. 113 (1938)
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Bronsted acidic ionic liquid catalyzed an eco-friendly and efficient procedure for synthesis of 2,4,5-trisubstituted imidazole derivatives under ultrasound irradiation and optimal conditions
Hilal,Hanoon
, p. 1521 - 1538 (2019/12/02)
Abstract: 2-[(1H-imidazol-3-ium-3-yl)methyl]-4-{bis[3-((1H-imidazol-3-ium-3-yl) methyl-(4-hydroxyphenyl]methylene}cyclohexa-2,5-dienone trihydrogen sulfate ([2-(imm)-4-{b(immh)m}c][HSO4]3), as the new Bronsted acidic ionic liquid, is effectively prepared and revealed by using FTIR, 1H NMR, SEM, EDS, XRD and mass data. Afterward, its catalytic activity was investigated for the synthesis of 2,4,5-trisubstituted imidazole derivatives via the simple reaction between different aldehydes, ammonium acetate and benzil/benzoin under ultrasound irradiation at ambient temperature and optimal conditions. The novel procedure has the advantages of high yields, easy handling, short reaction times, and being eco-friendly and economical. Moreover, the catalyst can be easily recovered for several times without any additional treatment. Graphic abstract: [Figure not available: see fulltext.].
Selective inhibition of the membrane attack complex of complement by low molecular weight components of the aurin tricarboxylic acid synthetic complex
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Paragraph 0040, (2013/03/26)
This patent pertains to selective inhibition of assembly of the membrane attack complex of complement by use of less than 1 kDa molecular weight forms of the aurin tricarboxylic acid synthetic complex (ATAC), and their derivatives. It further pertains to the use of these materials to treat human conditions where there is evidence of self destruction of host tissue by the membrane attack complex. These diseases include, but are not limited to, Alzheimer disease, age related macular degeneration, and atherosclerosis.
