122-25-8Relevant articles and documents
Synthesis of the covalent hydrate of the incorrectly assumed structure of Aurintricarboxylic Acid (ATA)
Cushman, Mark,Kanamathareddy, Suseela
, p. 1491 - 1498 (1990)
The triphenylcarbinol 6, which is the covalent hydrate of the generally accepted, but incorrect structure of aurintricarboxylic acid (ATA), has been synthesized and found to protect against the cytopathic effect of HIV-1 in CEM-V lymphocyte cell culture. The synthesis involved the first preparation of pure methylene disalicylic acid (5). The triphenylcarbinol 6 provides a novel lead, apart from (polymeric) ATA, for the development of potential anti-AIDS agents. The central carbinol oxygen of 6 did not exchange in the presence of excess oxygen-18 labelled water at room temperature even after seven days, indicating that there was no equilibration between 6 and 1 under these conditions.
METHOD FOR PRODUCING 5,5'-METHYLENEDISALICYLIC ACID
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Paragraph 0038-0054, (2020/05/20)
PROBLEM TO BE SOLVED: To provide a method for producing 5,5'-methylenedisalicylic acid, in which reactivity and reaction selectivity are improved. SOLUTION: The present invention relates to a method for producing 5,5'-methylenedisalicylic acid represented by formula (2), comprising a step of reacting a bisphenol F dialkali metal salt represented by formula (1) (in the formula, M represents sodium, potassium, lithium, rubidium, or cesium) and carbon dioxide in a reaction medium. SELECTED DRAWING: None COPYRIGHT: (C)2020,JPOandINPIT
Synthesis of novel bis-(1,3,4-oxadiazol-2-ylamino)-2-aryl-1,3 -thiazolan-4-ones as antimicrobial, nematicidal and anticancer agents
Kumar, Gaddam Rajesh,Shankar, Kurre,Reddy, Cherkupally Sanjeeva
, p. 700 - 714 (2019/05/22)
A series of novel bis-heterocycles, 3-(5-[2-methoxy-5-(4-methoxy-3-5-[(4-oxo-2-(aryl/hetaryl) -1,3-thiazolan -3- yl)animo]-l,3,4-oxadiazol-2-ylberizyl)phenyl]-l,3,4-oxadazol-2-ylamimo)-2-(aryl/lietaryl)-l,3-thizolan-4-ones 8a-j have been synthesized by simple and high yield routes. Structures of all the newly synthesized compounds have been established by their spectral data and elemental analysis, and they have been evaluated for their in vitro antimicrobial, nematicidal and anticancer activities. Among the tested compounds, those with 4-chlorophenyl (8c), 3-nitrophenyl (8d) and 2,4- difluorophenyl (8f) substituents at 2-position of thiazolidinone ring are found to be potent antibacterial and antifungal agents. Exploration of nematicidal activity of compounds 8a-j reveal that, compounds 8f, 8i and 8j bearing 2,4- difluorophenyl, 2-furyl and 1,3-benzodioxole substituents respectively at 2nd position of thiazolidinone ring show prominent activity comparable to the standard levamisole and have emerged as potential nematicidal agents. In vitro anticancer activity assay reveals that the compounds with electron-withdrawing groups viz., 4-chlorophenyl (8c), 3-nitrophenyl (8d) and 2,4- difluorophenyl (8f) display significant activity which is more than the standard against A549 (lung cancer) cell line, and compounds bearing electron-donating groups such as 4-methylphenyl (8b), 4-hydroxyphenyl (8e), N,N- dimethylaminophenyl (8g), and 4-methoxy-3-hydroxyphenyl (8h) show superior/comparable potency to the standard against MDAMB-231 (breast cancer) cell line. The docking scores estimated by Schr?dinger software also correlate well with the experimental anticancer activity.
Synthesis and antimicrobial activity of bis[4-methoxy-3-(6-aryl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-3-yl) phenyl]methanes and bis[(triazolo[3,4-b]thiadiazepin-3-yl) phenyl]methanes
Srinivas, Avula
, p. 173 - 179 (2016/03/19)
A series of novel bis[4-methoxy-3-(6-aryl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-3-yl)phenyl]methanes and bis[(triazolo[3,4-b]thiadiazepin-3-yl)phenyl]methanes (5a-e and 6a-e) has been synthesized and characterized by IR, 1H and 13C NMR, MS and elemental analysis. All the newly synthesized compounds were screened for their antibacterial activity against Bacillus subtilis, Staphylococcus aureus, Klobsinella aerogenes and Chromobacterium violaceum and antifungal activity against Candida albicans, Aspergillus fumigatus, Trichophyton rubrum and Trichophyton mentagrophytes. Compounds 5b, 5d, 5e, 6b, 6c and 6e exhibited potent activity against the tested bacteria and fungi, and emerged as potential molecules for further development.
