444002-96-4

Basic information

• Product Name: 1-(4-Cyanophenyl)-1H-pyridin-2-one
• Synonyms: 1-(4-Cyanophenyl)-1H-pyridin-2-one;4-(2-Oxo-1(2H)-pyridinyl)benzonitrile
• CAS NO: 444002-96-4
• Molecular Formula: C₁₂H₈N₂O
• Molecular Weight: 196.2
• Mol File: 444002-96-4.mol
• Article Data: 6

Chemical Properties

• Melting Point: 165-166℃
• Boiling Point: 424.443 °C at 760 mmHg
• Flash Point: 210.496 °C
• Appearance: /
• Density: 1.27
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.653
• CAS DataBase Reference: 1-(4-Cyanophenyl)-1H-pyridin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Cyanophenyl)-1H-pyridin-2-one(444002-96-4)
• EPA Substance Registry System: 1-(4-Cyanophenyl)-1H-pyridin-2-one(444002-96-4)

Safety Data

• Hazardous Substances Data: 444002-96-4(Hazardous Substances Data)

Usage

General Description

1-(4-Cyanophenyl)-1H-pyridin-2-one is a chemical compound with the molecular formula C12H8N2O. It is a yellow powder that is used in pharmaceutical research and development. 1-(4-Cyanophenyl)-1H-pyridin-2-one is a pyridinone derivative, which has potential applications in the fields of medicine and drug discovery. It has shown promise as an anti-inflammatory and analgesic agent, and its structure and properties make it a candidate for further exploration in medicinal chemistry. The compound's unique structure and potential bioactivity make it an interesting target for further study and synthesis of related compounds for pharmaceutical purposes.

InChI:InChI=1/C12H8N2O/c13-9-10-4-6-11(7-5-10)14-8-2-1-3-12(14)15/h1-8H

Upstream product

• 142-08-5 2-hydroxypyridin 
• 623-00-7 4-bromobenzenecarbonitrile 
• 3058-39-7 4-iodobenzonitrile 
• 1194-02-1 4-fluorobenzonitrile 
• 142-08-5 2-Pyridone 

Downstream Products

• 444002-97-5 1-(4-aminomethylphenyl)-1H-pyridin-2-one 
• 873009-42-8 C₁₂H₁₁N₃O₂ 

Relevant articles and documents

Rhodium(III)-Catalyzed Annulation of Pyridinones with Alkynes via Double C-H Activation: A Route to Functionalized Quinolizinones

A Rh(III)-catalyzed oxidative annulation of pyridin-2(1H)-ones with alkynes via double C-H activation to produce highly functionalized 4H-quinolizin-4-ones is disclosed. This reaction features easily available starting materials, simple manipulation, a relatively wide substrate scope, and good functional group tolerance. The application of this protocol is demonstrated by the synthesis of a known fluorescent quinolizino[3,4,5,6-ija]quinolinium salt.

FACTOR XA INHIBITORS

The present invention is directed to compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.

An improved Ullmann-Ukita-Buchwald-Li conditions for CuI-catalyzed coupling reaction of 2-pyridones with aryl halides

An effective CuI-trans-N,N′-dimethylcyclohexane-1,2-diamine (DMCDA)-K2CO3-catalyzed coupling reaction of 2-pyridones with aryl halides is described. Under our conditions, DMCDA was found to be an effective catalyst that facilitates the coupling reactions even in toluene, a common industrial solvent. In addition, 3-bromopyridine could also be coupled effectively under these conditions, indicating that the catalytic reactivity of this system is high. The reaction could be applied for polymer modification and iterative oligo-pyridone synthesis.