445423-03-0

Basic information

• Product Name: C₃₂H₄₉BO₂
• Synonyms: C₃₂H₄₉BO₂
• CAS NO: 445423-03-0
• Molecular Weight: 476.551
• Mol File: 445423-03-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₃₂H₄₉BO₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₂H₄₉BO₂(445423-03-0)
• EPA Substance Registry System: C₃₂H₄₉BO₂(445423-03-0)

Safety Data

• Hazardous Substances Data: 445423-03-0(Hazardous Substances Data)

Upstream product

• 116761-24-1 (R)-3-(benzyloxy)butanoic acid methyl ester 
• 862475-40-9 (R)-N-methoxy-N-methyl-3-benzyloxybutanamide 
• 87841-68-7 (4R)-4-(Benzyloxy)pentan-2-one 
• 112246-73-8 B-chlorodiisopinocampheylborane 

Downstream Products

• 445422-99-1 (2R,4S,8S,10R)-10-(t-butyldimethylsiloxy)-12-ethyl-4-hydroxy-8-methoxy-1-(p-methoxybenzyloxy)-2-(triethylsiloxy)-12-tridecen-6-one 
• 638222-34-1 (2R,4S,6R,8R,10S)-10-(tert-butyldimethylsilanyloxy)-2-(2-ethylprop-2-en-1-yl)-4-methoxy-8-(p-methoxybenzyloxymethyl)-1,7-dioxaspiro[5.5]undecane 
• 445423-09-6 (2R,4S,6R,8R,10S)-8-(2-ethylallyl)-10-methoxy-2-(p-methoxybenzyloxymethyl)-1,7-dioxaspiro[5.5]undecan-4-ol 
• 445422-98-0 (2R,4S,6S,8R,10S)-8-(2-ethylallyl)-10-methoxy-2-(p-methoxybenzyloxymethyl)-1,7-dioxaspiro[5.5]undecan-4-ol 
• 445423-06-3 (4R,6R,8R)-8-benzyloxy-4-(t-butyldimethylsiloxy)-2-ethyl-6-methoxy-1-nonene 
• 445423-05-2 (4R,6R,8R)-8-benzyloxy-2-ethyl-6-methoxy-4-propionoxy-1-nonene 
• 201354-99-6 1-[(2S,4S,6R,8R,10S)-10-(tert-butyldimethylsilanyloxy)-4-methoxy-8-(p-methoxybenzyloxymethyl)-1,7-dioxaspiro[5.5]undec-2-yl]butan-2-one 

Relevant articles and documents

The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: The CD-spiroacetal segment

Stereocontrolled syntheses of the C16-C28 CD-spiroacetal subunit of altohyrtin A/spongistatin 1 (1), relying on kinetic and thermodynamic control of the spiroacetal formation, are described. The kinetic control approach resulted in a slight preference (60: 40) for the desired spiroacetal isomer. The thermodynamic approach allowed ready access to the desired spiroacetal 2 by acid-promoted equilibration, Chromatographic separation of the C23 epimers and resubjection of the undesired isomer to the equilibration conditions. This scalable synthetic sequence provided multi-gram quantities of 2, thus enabling the successful completion of the total synthesis of altohyrtin A/spongistatin 1, as reported in Part 4 of this series. The Royal Society of Chemistry 2005.