445491-10-1

Basic information

• Product Name: 2-Propynoic acid, 3-(3,5-difluorophenyl)-, ethyl ester
• CAS NO: 445491-10-1
• Molecular Formula: C11H8F2O2
• Molecular Weight: 210.18
• Mol File: 445491-10-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Propynoic acid, 3-(3,5-difluorophenyl)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propynoic acid, 3-(3,5-difluorophenyl)-, ethyl ester(445491-10-1)
• EPA Substance Registry System: 2-Propynoic acid, 3-(3,5-difluorophenyl)-, ethyl ester(445491-10-1)

Safety Data

• Hazardous Substances Data: 445491-10-1(Hazardous Substances Data)

Upstream product

• 151361-87-4 1-ethynyl-3,5-difluorobenzene 

Relevant articles and documents

Substituted indoles and their use as integrin antagonists

The present invention relates to novel substituted indole compounds that are antagonists of alpha V (αv) integrins, for example αvβ3 and αvβ5 integrins, their pharmaceutically acceptable salts, and pharmaceutical compositions thereof. The compounds may be used in the treatment of pathological conditions mediated by αvβ3 and αvβ5 integrins, including such conditions as tumor growth, metastasis, restenosis, osteoporosis, inflammation, macular degeneration, diabetic retinopathy, and rheumatoid arthritis. The compounds have the general formula: where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, D, X, W, a, m, n, i, j, k and v are defined herein.