151361-87-4

Basic information

• Product Name: 1-ETHYNYL-3 5-DIFLUOROBENZENE 97
• Synonyms: 1-ETHYNYL-3 5-DIFLUOROBENZENE 97;1-Ethynyl-3,5-fluorobenzene;Benzene, 1-ethynyl-3,5-difluoro- (9CI);Benzene, 1-ethynyl-3,5-difluoro-;[3,5-Difluorophenyl]ethyne;1-Ethynyl-3,5-difluorobenzene 97%
• CAS NO: 151361-87-4
• Molecular Formula: C₈H₄F₂
• Molecular Weight: 138.1141664
• Product Categories: Alkynyl;Halogenated Hydrocarbons;Organic Building Blocks
• Mol File: 151361-87-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 123-124 °C(lit.)
• Flash Point: 78 °F
• Appearance: /liquid
• Density: 1.163 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.4910(lit.)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-ETHYNYL-3 5-DIFLUOROBENZENE 97(CAS DataBase Reference)
• NIST Chemistry Reference: 1-ETHYNYL-3 5-DIFLUOROBENZENE 97(151361-87-4)
• EPA Substance Registry System: 1-ETHYNYL-3 5-DIFLUOROBENZENE 97(151361-87-4)

Safety Data

• Hazard Codes: Xi
• Statements: 10-36/37/38
• Safety Statements: 16-26-36
• RIDADR: UN 1993 3/PG 3
• WGK Germany: 3
• HazardClass: 3
• PackingGroup: Ⅲ
• Hazardous Substances Data: 151361-87-4(Hazardous Substances Data)

Usage

Description

1-Ethynyl-3,5-difluorobenzene 97, also known as 1-ethynyl-3,5-difluorobenzene, is a light yellow liquid with unique chemical properties. It is a valuable research chemical that has potential applications in various fields due to its distinct structure and characteristics.

Uses

Used in Research and Development:
1-Ethynyl-3,5-difluorobenzene 97 is used as a research chemical for the development of new compounds and materials. Its unique structure and properties make it a promising candidate for further exploration and experimentation in the field of chemistry.
Used in Pharmaceutical Industry:
1-Ethynyl-3,5-difluorobenzene 97 is used as an intermediate in the synthesis of various pharmaceutical compounds. Its specific chemical properties allow it to be a key component in the development of new drugs and medications.
Used in Chemical Industry:
1-Ethynyl-3,5-difluorobenzene 97 is used as a building block in the chemical industry for the production of various specialty chemicals and materials. Its unique properties make it suitable for use in the creation of advanced materials with specific characteristics and applications.
Used in Material Science:
1-Ethynyl-3,5-difluorobenzene 97 is used as a component in the development of new materials with specific properties, such as enhanced strength, durability, or chemical resistance. Its unique structure and properties contribute to the advancement of material science and the creation of innovative materials for various applications.

Upstream product

• 445491-09-8 [2-(3,5-difluorophenyl)ethynyl]trimethylsilane 
• 461-96-1 3,5-difluorobromobenzene 
• 1066-54-2 trimethylsilylacetylene 
• 32085-88-4 3,5-difluorobenzaldehyde 

Downstream Products

• 151361-94-3 Acetic acid (2R,3S,5R)-2-acetoxymethyl-5-[5-(3,5-difluoro-phenylethynyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester 
• 324529-53-5 5-bromo-5-(3,5-difluorophenyl)-1-(4-methylsulfanylphenyl)pent-4-en-1-one 
• 212126-32-4 2-(3,5-difluorophenyl)-3-(4-(methylsulfonyl)phenyl)-2-cyclopenten-1-one 
• 228717-97-3 2-(3',5'-difluorophenyl)-3-(4'-methylthiophenyl)cyclopent-2-en-1-one 
• 324529-54-6 2-(3,5-difluorophenyl)-1-(4-methylsulfanylphenyl)cyclopent-2-enol 
• 445491-10-1 (3,5-difluoro-phenyl)-propynoic acid ethyl ester 
• 1040744-23-7 4-[4-(3,5-difluorophenyl)-[1,2,3]triazol-1-yl]-4'-trifluoromethylbiphenyl-3-carbonitrile 
• 1037183-89-3 2-tert-butoxycarbonylamino-5-[2-(3,5-difluorophenylethynyl)phenyl]imidazole-1-carboxylic acid tert-butyl ester 
• 1037183-90-6 2-tert-butoxycarbonylamino-5-[3-(3,5-difluorophenylethynyl)phenyl]imidazole-1-carboxylic acid tert-butyl ester 
• 1037183-91-7 2-tert-butoxycarbonylamino-5-[4-(3,5-difluorophenylethynyl)phenyl]imidazole-1-carboxylic acid tert-butyl ester 
• 1015419-89-2 (S,E)-N-(7-(3,5-difluorophenyl)-2,3,8,8a-tetrahydroindolizin-5(1H)-ylidene)-2-methoxyaniline 

Relevant articles and documents

Anionic sigmatropic-electrocyclic-chugaev cascades: Accessing 12-aryl-5-(methylthiocarbonylthio)tetracenes and a related anthra[2,3-b]thiophene

1,4-Diols resulting from the double addition of ArCCLi (Ar = Ph, substituted phenyl, 2-thienyl) to ortho-C6H4(CHO)2 undergo cascades to tetracenes on simple admixture of LiHDMS, CS2 and MeI. Acene formation proceeds by [3,3]-sigmatropic rearrangement of xanthate anions followed by 6π electrocyclisations. The reactions are terminated by E2 or anionic Chugaev-type eliminations. Structural packing motifs and electronic properties are reported for the tetracenes.

Substituted indoles and their use as integrin antagonists

The present invention relates to novel substituted indole compounds that are antagonists of alpha V (αv) integrins, for example αvβ3 and αvβ5 integrins, their pharmaceutically acceptable salts, and pharmaceutical compositions thereof. The compounds may be used in the treatment of pathological conditions mediated by αvβ3 and αvβ5 integrins, including such conditions as tumor growth, metastasis, restenosis, osteoporosis, inflammation, macular degeneration, diabetic retinopathy, and rheumatoid arthritis. The compounds have the general formula: where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, D, X, W, a, m, n, i, j, k and v are defined herein.

Palladium-catalyzed coupling of terminal alkynes with 5-(trifluoromethanesulfonyloxy) pyrimidine nucleosides

-