324529-54-6

Basic information

• Product Name: 2-(3,5-difluorophenyl)-1-(4-methylsulfanylphenyl)cyclopent-2-enol
• Synonyms: 2-(3,5-difluorophenyl)-1-(4-methylsulfanylphenyl)cyclopent-2-enol
• CAS NO: 324529-54-6
• Molecular Weight: 318.387
• Mol File: 324529-54-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(3,5-difluorophenyl)-1-(4-methylsulfanylphenyl)cyclopent-2-enol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,5-difluorophenyl)-1-(4-methylsulfanylphenyl)cyclopent-2-enol(324529-54-6)
• EPA Substance Registry System: 2-(3,5-difluorophenyl)-1-(4-methylsulfanylphenyl)cyclopent-2-enol(324529-54-6)

Safety Data

• Hazardous Substances Data: 324529-54-6(Hazardous Substances Data)

Upstream product

• 151361-87-4 1-ethynyl-3,5-difluorobenzene 
• 461-96-1 3,5-difluorobromobenzene 
• 21573-80-8 1-(4-methylthiophenyl)propenone 
• 1442-06-4 4-(methylthio)benzoyl chloride 
• 13205-48-6 4-(methylthio)benzoic acid 
• 324529-53-5 5-bromo-5-(3,5-difluorophenyl)-1-(4-methylsulfanylphenyl)pent-4-en-1-one 

Downstream Products

• 212126-32-4 2-(3,5-difluorophenyl)-3-(4-(methylsulfonyl)phenyl)-2-cyclopenten-1-one 
• 228717-97-3 2-(3',5'-difluorophenyl)-3-(4'-methylthiophenyl)cyclopent-2-en-1-one 

Relevant articles and documents

A three-component coupling approach to cyclopentanoids

A new approach to 2,3-disubstituted cyclopentenones has been developed. This approach consists of a two-step protocol involving the cyclization of a Z-vinyl bromide under Barbier type conditions to form a cyclopentenol, which is then oxidatively rearranged to generate the cyclopentenone. The Z-vinyl bromide is in turn derived from a ruthenium catalyzed three-component coupling of an alkyne, an enone, and a HBr equivalent. A range of 2,3-disubstituted cyclopentenones has been generated, including short syntheses of jasmone and dihydrojasmone. Further applicability of this strategy is shown in the total syntheses of tetrahydrodicranenone B, rosaprostol, and a selective COX-2 inhibitor.