4458-31-5 Usage
Description
N-(N-PROPYL)DIETHYLAMINE, also known as N-Propyldiethylamine, is a tertiary amine derived from propylamine, where the two amino hydrogens are replaced by ethyl groups. It is an organic compound with a wide range of applications across different industries due to its unique chemical properties.
Uses
Used in Chemical Synthesis:
N-(N-PROPYL)DIETHYLAMINE is used as a building block for the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and other specialty chemicals. Its amine functional group allows for easy modification and reaction with other molecules, making it a versatile component in the creation of complex structures.
Used in Solvent Applications:
In the solvent industry, N-(N-PROPYL)DIETHYLAMINE is used as a solvent for various chemical reactions, particularly those involving organometallic compounds. Its ability to dissolve a wide range of substances and its relatively low toxicity compared to other solvents make it a preferred choice in certain applications.
Used in Catalyst Applications:
N-(N-PROPYL)DIETHYLAMINE is used as a catalyst in various chemical reactions, such as esterification, transesterification, and hydrogenation processes. Its basic nature and steric properties enable it to facilitate the reaction between substrates, leading to improved reaction rates and selectivity.
Used in the Pharmaceutical Industry:
N-(N-PROPYL)DIETHYLAMINE is used as an intermediate in the synthesis of various pharmaceutical compounds, including drugs for the treatment of central nervous system disorders, cardiovascular diseases, and other medical conditions. Its unique structure allows for the development of novel drug candidates with improved efficacy and safety profiles.
Used in the Agrochemical Industry:
In the agrochemical sector, N-(N-PROPYL)DIETHYLAMINE is used as a starting material for the synthesis of various pesticides, herbicides, and insecticides. Its ability to form stable complexes with other molecules enables the development of more effective and targeted agrochemical products.
Used in the Dye and Pigment Industry:
N-(N-PROPYL)DIETHYLAMINE is used as a precursor in the production of dyes and pigments, particularly those with specific color properties and stability. Its amine functionality allows for the creation of a wide range of colorants with diverse applications in the textile, plastics, and printing industries.
Check Digit Verification of cas no
The CAS Registry Mumber 4458-31-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,4,5 and 8 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 4458-31:
(6*4)+(5*4)+(4*5)+(3*8)+(2*3)+(1*1)=95
95 % 10 = 5
So 4458-31-5 is a valid CAS Registry Number.
InChI:InChI=1/C7H17N/c1-4-7-8(5-2)6-3/h4-7H2,1-3H3
4458-31-5Relevant articles and documents
Catalytic reduction of amides to amines by electrophilic phosphonium cations via FLP hydrosilylation
Augurusa, Alessandra,Mehta, Meera,Perez, Manuel,Zhu, Jiangtao,Stephan, Douglas W.
supporting information, p. 12195 - 12198 (2016/10/21)
A catalytic methodology for the conversion of amides to amines is reported. Of the 25 examples described, 14 examples involve the reduction of N-trifluoroacetamides to the corresponding trifluoroethylamines. These reductions are achieved by catalytic hydrosilylation of the amide mediated by an electrophilic phosphonium cation (EPC) catalyst.
Catalytic hydrogenation of amides to amines under mild conditions
Stein, Mario,Breit, Bernhard
supporting information, p. 2231 - 2234 (2013/03/28)
Under (not so much) pressure: A general method for the hydrogenation of tertiary and secondary amides to amines with excellent selectivity using a bimetallic Pd-Re catalyst has been developed. The reaction proceeds under low pressure and comparatively low temperature. This method provides organic chemists with a simple and reliable tool for the synthesis of amines. Copyright
Selective hydrogenation of amides using ruthenium/ molybdenum catalysts
Beamson, Graham,Papworth, Adam J.,Philipps, Charles,Smith, Andrew M.,Whyman, Robin
experimental part, p. 869 - 883 (2010/07/05)
Recyclable, heterogeneous bimetallic ruthenium/molybdenum catalysts, formed in situ from triruthenium dodecacarbonyl [Ru3(CO)12] and molybdenum hexacarbonyl [Mo(CO)6], are effective for the selective liquid phase hydrogenation of cyclohexylcarboxamide (CyCONH2) to cyclohexanemethylamine (CyCH2NH2), with no secondary or tertiary amine by-product formation. Variation of Mo:Ru composition reveals both synergistic and poisoning effects, with the optimum combination of conversion and selectivity at ca. 0.5, and total inhibition of catalysis evident at ≥1. Good amide conversions are noted within the reaction condition regimes 20100 bar hydrogen and 145-160°C. The order of reactivity of these catalysts towards reduction of different amide functional groups is primary > tertiary ? secondary. In situ HP-FT-IR spectroscopy confirms that catalyst genesis occurs during an induction period associated with decomposition of the organometallic precursors. Ex situ characterisation, using XRD, XPS and EDX-STEM, for active Mo:Ru compositions, has provided evidence for intimately mixed ca. 2.5-4 nm particles that contain metallic ruthenium, and molybdenum (in several oxidation states, including zero).
