448956-63-6Relevant articles and documents
Optimization and metabolic stabilization of a class of nonsteroidal glucocorticoid modulators
Link,Sorensen, Bryan K.,Patel, Jyoti,Arendsen, David,Li, Gaoquan,Swanson, Susan,Nguyen, Bach,Emery, Maurice,Grynfarb, Marlena,Goos-Nilsson, Annika
, p. 4169 - 4172 (2007/10/03)
The optimization of a series of nonsteroidal glucocorticoid modulators is reported. Potent selective GR ligands that have improved metabolic stability were discovered typified by the subnanomolar acid 12 (GR binding IC 50=0.6nM).