449729-48-0Relevant articles and documents
A highly stereocontrolled total synthesis of (+)-biotin from L-cysteine
Seki, Masahiko,Hatsuda, Masanori,Mori, Yoshikazu,Yamada, Shin-Ichi
, p. 3269 - 3272 (2007/10/03)
(+)-Biotin was synthesized in 11 steps and in 25% overall yield from readily accessible L-cysteine through a Lewis base-catalyzed highly diastereoselective cyanosilylation of (2R,4R)-N-Boc-2-phenylthiazolidine-4-carbaldehyde 2 and a ring closure of a cis-allylic carbonate 5b utilizing a palladium-catalyzed intramolecular allylic amination.