151415-02-0Relevant articles and documents
A Novel Enantioselective Synthesis of (+)-Biotin
Deroose, Frederik D.,Clercq, Pierre J. De
, p. 4365 - 4368 (1993)
A conceptually simple enantioselective 14-step synthesis of (+)-biotin from L-cysteine is reported based upon an intramolecular 1,3-dipolar cyclodaddition sequence involving (i) elimination of bromide 8 to the endocyclic thioenol ether 9, (ii) thermolysis of the ene carbamoyl azide 9 to the exocyclic thioenol ether 10.Both the synthesis of 8 and the final transformation of 10 into (+)-biotin are based upon literature precedents.
