450842-25-8

Basic information

• Product Name: Benzonitrile, 3-(1,3-benzodioxol-5-yl)-4-hydroxy-
• CAS NO: 450842-25-8
• Molecular Formula: C14H9NO3
• Molecular Weight: 239.23
• Mol File: 450842-25-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzonitrile, 3-(1,3-benzodioxol-5-yl)-4-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzonitrile, 3-(1,3-benzodioxol-5-yl)-4-hydroxy-(450842-25-8)
• EPA Substance Registry System: Benzonitrile, 3-(1,3-benzodioxol-5-yl)-4-hydroxy-(450842-25-8)

Safety Data

• Hazardous Substances Data: 450842-25-8(Hazardous Substances Data)

Upstream product

• 450842-21-4 3-(1,3-benzodioxol-5-yl)-4-(ethoxymethoxy)benzonitrile 
• 94839-07-3 3,4-(methylenedioxy)-benzeneboronic acid 
• 82504-06-1 3-iodo-4-methoxybenzonitrile 
• 565203-80-7 3-benzo[1,3]dioxol-5-yl-4-methoxy-benzonitrile 

Downstream Products

• 450842-29-2 3-(1,3-benzodioxol-5-yl)-4-(2-(4-cyanophenyl)-2-oxoethoxy)benzonitrile 
• 565203-97-6 3-benzo[1,3]dioxol-5-yl-4-trimethylsilanylethynyl-benzonitrile 
• 565204-04-8 3-benzo[1,3]dioxol-5-yl-4-ethynyl-benzonitrile 
• 565203-90-9 trifluoro-methanesulfonic acid 2-benzo[1,3]dioxol-5-yl-4-cyano-phenyl ester 

Relevant articles and documents

Synthesis and biological evaluation of 4-[3-biphenyl-2-yl-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-1- yl-benzonitrile as novel farnesyltransferase inhibitor

Farnesyltransferase inhibitors (FTIs) have emerged as a novel class of anti-cancer agents. Analogues of the potent FTI, 4-[3-biphenyl-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-1-yl- benzonitrile, were synthesized and tested in vitro for their inhibitory activities. The synthesis and detailed biological data of this series of analogues are presented.

Farnesyltransferase inhibitors

Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.