452100-87-7Relevant articles and documents
Synthetic studies on d-biotin, part 9.1) An improved asymmetric synthetic route to d-biotin via Hoffmann-Roche lactone-thiolactone approach
Chen, Fen-Er,Jia, Hui-Qing,Chen, Xu-Xiang,Dai, Hui-Fang,Xie, Bin,Kuang, Yun-Yan,Zhao, Jian-Feng
, p. 743 - 746 (2007/10/03)
An efficient and highly stereoselective total synthesis of d-biotin has been achieved starting from cis-1,3-dibenzyl-2-imidazolidone-4,5-dicarboxylic acid (2) with an overall yield of 33%. Polymer-supported oxazaborolidine- catalyzed asymmetric reduction of meso-cyclic imide 4 constitutes the key synthetic step in introducing stereogenic centers into the d-biotin molecule.