45521-09-3

Basic information

• Product Name: D-THIAZOLIDINE-4-CARBOXYLIC ACID
• Synonyms: D-THIAPROLINE;D-THIAZOLIDINE-4-CARBOXYLIC ACID;D-THIOPROLINE;H-D-THZ-OH;d-4-thiazolidinecarboxylicaci;D-Hepalidine;(4S)-1,3-thiazolidine-4-carboxylic acid;(S)-4-Thiazolidinecarboxylic Acid
• CAS NO: 45521-09-3
• Molecular Formula: C₄H₇NO₂S
• Molecular Weight: 133.17
• EINECS: 256-240-3
• Product Categories: Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 45521-09-3.mol
• Article Data: 23

Chemical Properties

• Boiling Point: 350.3 °C at 760 mmHg
• Flash Point: 165.7 °C
• Appearance: /
• Density: 1.38 g/cm³
• Vapor Pressure: 7.63E-06mmHg at 25°C
• Refractive Index: 1.565
• Storage Temp.: Store at 0-5°C
• CAS DataBase Reference: D-THIAZOLIDINE-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: D-THIAZOLIDINE-4-CARBOXYLIC ACID(45521-09-3)
• EPA Substance Registry System: D-THIAZOLIDINE-4-CARBOXYLIC ACID(45521-09-3)

Safety Data

• Hazardous Substances Data: 45521-09-3(Hazardous Substances Data)

Usage

Description

D-THIAZOLIDINE-4-CARBOXYLIC ACID, also known as an optically active version of thioproline with D-configuration, is a thiazolidine derivative that exhibits inhibitory effects on blood platelet aggregation. It is characterized by its unique chemical structure and properties, making it a valuable compound for various applications in different industries.

Uses

Used in Pharmaceutical Industry:
D-THIAZOLIDINE-4-CARBOXYLIC ACID is used as a therapeutic agent for its ability to inhibit blood platelet aggregation. This property makes it a potential candidate for the development of drugs aimed at treating conditions related to blood clotting, such as thrombosis and atherosclerosis.
Used in Chemical Research:
D-THIAZOLIDINE-4-CARBOXYLIC ACID is used as a ligand in the catalytic asymmetric reduction of ketones with borane. This application is significant in the field of chemical research, as it allows for the synthesis of enantiomerically pure compounds, which are essential in the development of pharmaceuticals and other specialty chemicals.
Used in Material Science:
The unique properties of D-THIAZOLIDINE-4-CARBOXYLIC ACID also make it a potential candidate for use in the development of new materials with specific characteristics, such as improved mechanical strength or chemical resistance. Further research and development in this area could lead to innovative applications in various industries, including automotive, aerospace, and electronics.

InChI:InChI=1/C4H7NO2S/c6-4(7)3-1-8-2-5-3/h3,5H,1-2H2,(H,6,7)/t3-/m1/s1

Upstream product

• 50-00-0 formaldehyd 
• 52-89-1 l-cysteine hydrochloride 
• 34592-47-7 L-thioproline 
• 921-01-7 rac-cysteine 
• 444-27-9 (RS)-4-thiazolidinecarboxylic acid 
• 10318-18-0 DL-cysteine hydrochloride 
• 114192-98-2 (2R,3R)-2,3-Dihydroxy-succinic acid; compound with (S)-thiazolidine-4-carboxylic acid 
• 32443-99-5 D-cysteine hydrochloride 
• 52-89-1 L-cysteine hydrochloride 

Downstream Products

• 119616-17-0 3-benzoyl-thiazolidine-4-carboxylic acid 
• 122230-48-2 3-phenylacetyl-thiazolidine-4-carboxylic acid 
• 119910-75-7 1,2,3,3aα,4α,8,8aβ,8bα-octahydro-2-methyl-4-phenylpyrrolo<3',4':3,4>pyrrolo<1,2-c>thiazole-1,3-dione 
• 119910-75-7 1,2,3,3aα,4β,8aα,8bα-octahydro-2-methyl-4-phenylpyrrolo<3',4':3,4>pyrrolo<1,2-c>thiazole-1,3-dione 
• 137441-54-4 C₃₁H₃₈N₂O₃S 
• 110822-04-3 N-(5-methyl-2-nitrobenzoyl)thiazolidine-4-carboxylic acid 
• 88381-44-6 N-nitrosothiazolidine-4-carboxylic acid 
• 640-61-9 N-methyl-p-toluenesulfonylamide 
• 5025-82-1 N-acetyl-thiazolidine-4-carboxylic acid 
• 131570-70-2 (4aS,7aS,8R,8aR)-8-Phenyl-hexahydro-cyclopenta[4,5]pyrrolo[1,2-c]thiazol-7-one 
• 131570-71-3 (1S,6R,7R,11R)-11-Phenyl-4-thia-2-aza-tricyclo[5.3.1.0^2,6]undecan-8-one 
• 110822-07-6 N-(5-methyl-2-nitrobenzyl)thiazolidine-4-carboxylic acid 
• 51977-23-2 6-phenyl-1H,3H-imidazo<1,5-c>thiazole-5,7-<6H,7aH>-dione 
• 86634-64-2 Tetrahydro-6-phenyl-5-thioxoimidazo[1,5-c]thiazol-7(3H)-one 

Relevant articles and documents

PROCESS FOR PURIFYING (METH)ACRYLIC ACID

A process for producing a grade of (meth)acrylic acid having residual formaldehyde levels of under 100 parts per million.

EFFICIENT SYNTHESIS OF CHELATORS FOR NUCLEAR IMAGING AND RADIOTHERAPY: COMPOSITIONS AND APPLICATIONS

Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

NOVEL DIPEPTIDYL PEPTIDASE IV INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESS FOR THEIR PREPARATION

The present invention relates to novel compounds useful as dipeptidyl peptidase IV (DPP-IV) inhibitors of the formula: (I) wherein Y is -S(O)m, -CH2-, CHF, or -CF2; m is 0, 1, or 2; X is a bond, C1-C5 alkyl (e.g., -CH2-), or -C(=0)-; the dotted line [----] in the carbocyclic ring represents an optional double bond; R1 is substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkylalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocyclic ring, substituted or unsubstituted heterocyclylalkyl, substituted or unsubstituted heteroarylalkyl, CN, -COOR3, CONR3R4, -OR3, -NR3R4, or NR3COR3; R2 is hydrogen, cyano, COOH, or an isostere of a carboxylic acid (such as SO3H, CONOH, B(OH)2, PO3R3R4, SO2NR3R4, tetrazole, -COOR3, -CONR3R4, NR3COR4, or -COOCOR3).