457059-31-3Relevant articles and documents
Trifluoromethyl-substituted hydantoins, versatile building blocks for rational drug design
Wehner, Volkmar,Stilz, Hans-Ulrich,Osipov, Sergej N.,Golubev, Alexander S.,Sieler, Joachim,Burger, Klaus
, p. 4295 - 4302 (2007/10/03)
Preparatively simple, one-pot syntheses of trifluoromethyl-substituted hydantoins starting from Boc-protected imines of hexafluoroacetone and trifluoropyruvate are described. They represent valuable building blocks for the construction of constrained pept