457059-32-4

Basic information

• Product Name: ethyl (S)-3-((S)-2-(4,4-bis(trifluoromethyl)-3-(4-(3-(2-methylphenyl)ureido)-3-methoxybenzyl)-2,5-dioxoimidazolidin-1-yl)-2-(cyclopropylmethyl)acetylamino)-3-phenylpropionate
• Synonyms: ethyl (S)-3-((S)-2-(4,4-bis(trifluoromethyl)-3-(4-(3-(2-methylphenyl)ureido)-3-methoxybenzyl)-2,5-dioxoimidazolidin-1-yl)-2-(cyclopropylmethyl)acetylamino)-3-phenylpropionate
• CAS NO: 457059-32-4
• Molecular Weight: 791.747
• Mol File: 457059-32-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: ethyl (S)-3-((S)-2-(4,4-bis(trifluoromethyl)-3-(4-(3-(2-methylphenyl)ureido)-3-methoxybenzyl)-2,5-dioxoimidazolidin-1-yl)-2-(cyclopropylmethyl)acetylamino)-3-phenylpropionate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (S)-3-((S)-2-(4,4-bis(trifluoromethyl)-3-(4-(3-(2-methylphenyl)ureido)-3-methoxybenzyl)-2,5-dioxoimidazolidin-1-yl)-2-(cyclopropylmethyl)acetylamino)-3-phenylpropionate(457059-32-4)
• EPA Substance Registry System: ethyl (S)-3-((S)-2-(4,4-bis(trifluoromethyl)-3-(4-(3-(2-methylphenyl)ureido)-3-methoxybenzyl)-2,5-dioxoimidazolidin-1-yl)-2-(cyclopropylmethyl)acetylamino)-3-phenylpropionate(457059-32-4)

Safety Data

• Hazardous Substances Data: 457059-32-4(Hazardous Substances Data)

Upstream product

• 457059-29-9 tert-butyl (S)-2-[4,4-bis(trifluoromethyl)-2,5-dioxo-1,3-imidazolidin-1-yl]-2-(cyclopropylmethyl)acetate 
• 457059-30-2 (S)-2-[4,4-bis(trifluoromethyl)-2,5-dioxo-1,3-imidazolidin-1-yl]-2-(cyclopropylmethyl)acetic acid 
• 306769-05-1 4-[3-(2-methylphenyl)ureido]-3-methoxybenzyl chloride 
• 306769-04-0 4-[3-(2-methylphenyl)ureido]-3-methoxybenzyl alcohol 
• 457059-28-8 tert-butyl (S)-3-N-formyl-3-cyclopropylalaninate 
• 710334-45-5 3-cyclopropyl-2-isocyano-propionic acid tert-butyl ester 
• 102735-53-5 (2S)-2-amino-3-cyclopropylpropanoic acid 
• 80866-88-2 (3-methoxy-4-nitrophenyl)methanol 
• 3082-69-7 ethyl (3S)-3-amino-3-phenylpropionate 
• 457059-31-3 (S)-2-[4,4-bis(trifluoromethyl)-3-(4-(3-(2-methylphenyl)ureido)-3-methoxybenzyl)-2,5-dioxoimidazolidin-1-yl]-2-(cyclopropylmethyl)acetic acid 

Relevant articles and documents

Trifluoromethyl-substituted hydantoins, versatile building blocks for rational drug design

Preparatively simple, one-pot syntheses of trifluoromethyl-substituted hydantoins starting from Boc-protected imines of hexafluoroacetone and trifluoropyruvate are described. They represent valuable building blocks for the construction of constrained pept

Bis(trifluoromethyl)hydantoins as intermediates for pharmaceutically active ingredients

The present invention relates to hydantoins of formula I, in which R is the residue of an amino carboxylic acid or of an amino carboxylic acid derivative, which is obtained formally by removing an NH2 group from an amino carboxylic acid or an amino carboxylic acid derivative, to the preparation thereof and to the use thereof as intermediates, in particular for preparing pharmaceutically active ingredients.