46122-65-0

Basic information

• Product Name: 4-Vinylbenzeneacetic acid
• Synonyms: 4-Vinylbenzeneacetic acid;4-Ethenylbenzeneacetic acid;(4-Vinylphenyl)acetic acid;(p-Vinylphenyl)acetic acid
• CAS NO: 46122-65-0
• Molecular Weight: 162.188
• EINECS: -0
• Mol File: 46122-65-0.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 4-Vinylbenzeneacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Vinylbenzeneacetic acid(46122-65-0)
• EPA Substance Registry System: 4-Vinylbenzeneacetic acid(46122-65-0)

Safety Data

• Hazardous Substances Data: 46122-65-0(Hazardous Substances Data)

Usage

General Description

4-Vinylbenzeneacetic acid is a chemical compound with the molecular formula C10H10O2. It is a derivative of styrene and belongs to the class of vinylbenzenes. 4-Vinylbenzeneacetic acid is commonly used in the production of polymers and resins, as well as in the synthesis of various pharmaceuticals and agrochemicals. It is also used as a starting material for the preparation of other organic compounds. 4-Vinylbenzeneacetic acid is considered a hazardous chemical and should be handled with caution due to its potential health and environmental risks.

Upstream product

• 1592-11-6 (4-vinyl-phenyl)-acetonitrile 
• 124-38-9 carbon dioxide 
• 1592-20-7 4-Vinylbenzyl chloride 
• 1241937-59-6 4-(benzene-sulfonyl-methyl)styrene 
• 6336-45-4 vinylboronic acid dibutyl ester 
• 1878-68-8 2-(4-bromophenyl)-acetic acid 
• 62667-42-9 4-vinyl(phenyl)acetic acid methyl ester 
• 20051-06-3 p-Methoxycarbonylmethyl acetophenone 

Downstream Products

• 62667-41-8 p-Vinylphenylperessigsaeure-tert.-butylester 
• 1602485-06-2 C₁₁H₁₀F₃N₃O₂ 
• 101431-70-3 2-acetyl-3-oxo-4-(4-vinyl-phenyl)-butyric acid ethyl ester 
• 1580534-50-4 trimethyl 2,2’,2’’-{[(1E,1’E,1’’E)-benzene-1,3,5-triyltris(ethene-2,1-diyl)]tris(benzene-4,1-diyl)}triacetate 
• 1580534-34-4 2,2’,2’’-{[(1E,1’E,1’’E)-benzene-1,3,5-triyltris(ethene-2,1-diyl)]tris(benzene-4,1-diyl)}triacetic acid 
• 152845-13-1 (4-vinylphenyl)acetic acid tert-butyl ester 
• 1272015-95-8 (4-{2-[4-(2-{4-[(9H-fluoren-9-ylmethoxycarbonylamino)methyl]phenyl}vinyl)-2,5-dimethoxyphenyl]vinyl}phenyl)acetic acid 
• 1272015-83-4 {4-[2-(4-{2-[4-(tert-butoxycarbonylaminomethyl)phenyl]vinyl}-2,5-dimethoxyphenyl)vinyl]phenyl}acetic acid tert-butyl ester 
• 1208549-01-2 C₁₄H₁₃NO₄ 
• 15824-17-6 4-phenethylstyrene 
• 663951-24-4 monomethyl 2-methyl-2-(4-vinylphenyl)malonate 
• 663951-33-5 methyl 2-(4-vinylphenyl)propionate 
• 62667-42-9 4-vinyl(phenyl)acetic acid methyl ester 

Relevant articles and documents

Desulfonylative Electrocarboxylation with Carbon Dioxide

Electrocarboxylation of organic halides is one of the most investigated electrochemical approaches for converting thermodynamically inert carbon dioxide (CO2) into value-added carboxylic acids. By converting organic halides into their sulfone derivatives, we have developed a highly efficient electrochemical desulfonylative carboxylation protocol. Such a strategy takes advantage of CO2as the abundant C1 building block for the facile preparation of multifunctionalized carboxylic acids, including the nonsteroidal anti-inflammatory drug ibuprofen, under mild reaction conditions.

Silver encapsulated copper salen complex: Efficient catalyst for electrocarboxylation of cinnamyl chloride with CO2

An active catalyst, [Cu]?Ag composite, was synthesized for the first time and used as a cathode for electrocarboxylation of cinnamyl chloride with CO2. β,γ-Unsaturated carboxylic acids were obtained with excellent yield and moderate selectivity. Moreover, reasonable yields and selectivities of carboxylic acids were also achieved with several allylic halides and aryl halides.

Palladium-Catalyzed Carboxylation of Benzyl Chlorides with Atmospheric Carbon Dioxide in Combination with Manganese/Magnesium Chloride

An efficient direct carboxylation of a series of benzyl chlorides with CO2 catalyzed by Pd(OAc)2/dicyclohexyl (2′,6′-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine (SPhos) was developed to afford the corresponding phenylacetic acids in combination with Mn powder as a reducing reagent and MgCl2 as an indispensable additive. The reaction proceeded smoothly under 1 atm CO2. The application of Mn powder instead of a sensitive reducing reagent represents an operationally simple access to phenylacetic acids. Notably, MgCl2 is able to stabilize the (SPhos)2PdII(Bn)(Cl)(η1-CO2)(MgCl2) adduct and thus facilitates CO2 insertion into the PdII-C bond, which is supported by a DFT study. Specific effect: MgCl2 facilitates the direct insertion of CO2 into the PdII-C bond by stabilizing the PdII-CO2 adduct. With MgCl2 as an indispensable additive, the Pd-catalyzed carboxylation of various benzyl chlorides proceeded smoothly under 1 atm CO2, and the application of Mn powder instead of a sensitive reducing reagent makes this protocol an operationally simple access to phenylacetic acids.