46886-82-2

Basic information

• Product Name: 1H-Indole-3-ethanol, a-phenyl-
• CAS NO: 46886-82-2
• Molecular Formula: C16H15NO
• Molecular Weight: 237.301
• Mol File: 46886-82-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1H-Indole-3-ethanol, a-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-3-ethanol, a-phenyl-(46886-82-2)
• EPA Substance Registry System: 1H-Indole-3-ethanol, a-phenyl-(46886-82-2)

Safety Data

• Hazardous Substances Data: 46886-82-2(Hazardous Substances Data)

Upstream product

• 83-34-1 3-Methylindole 
• 100-52-7 benzaldehyde 
• 120-72-9 indole 
• 96-09-3 styrene oxide 
• 13735-81-4 1-styrenyloxytrimethylsilane 
• 132922-37-3 2-(1H-indol-3-yl)-N-methoxy-N-methyl-acetamide 
• 63336-26-5 1-phenyl-2-(1H-indol-3-yl)ethan-1-one 
• 87-51-4 indole-3-acetic acid 
• 100-58-3 phenylmagnesium bromide 
• 88730-73-8 3-Hydroxy-3-(2-oxo-2-phenyl-ethyl)-1,3-dihydro-indol-2-one 
• 98-86-2 acetophenone 
• 91-56-5 indole-2,3-dione 

Relevant articles and documents

Asymmetric transfer hydrogenation of heterocycle-containing acetophenone derivatives using N-functionalised [(benzene)Ru(II)(TsDPEN)] complexes

The application of enantiomerically-pure ruthenium(II) catalysts containing N - functionalised TsDPEN ligand to the asymmetric transfer hydrogenation of 15 examples of α-heterocyclic acetophenone derivatives is reported. Products of up to 99% ee were formed.

Acid-catalyzed highly diastereoselective and effective synthesis of 1,3-disubstituted tetrahydropyrano[3,4-b]indoles

We successfully explored for the first time that trifluoroacetic acid (TFA) can effectively catalyze the oxa-Pictet-Spengler reaction of secondary tryptophols and acetals to synthesize 1,3-disubstituted 1,3,4,9-tetrahydropyrano[3,4-b]indoles in high yield (up to >99%) and diastereoselectivity (>20:1). The secondary tryptophols were synthesized from indole-3-acetic acid. The one-pot synthesis of tetrahydropyrano[3,4-b]indoles was successfully developed from secondary tryptophols and in situ prepared acetals from aldehydes and trimethylorthoformate and thus the cost-efficiency of the protocol was effectively enhanced. Finally, the catalytic asymmetric synthesis of the 1,3-disubstituted tetrahydropyrano[3,4-b]indole was also demonstrated after enantioselective achievement of highly enantiopure secondary tryptophols.