63336-26-5

Basic information

• Product Name: Ethanone, 2-(1H-indol-3-yl)-1-phenyl-
• CAS NO: 63336-26-5
• Molecular Formula: C16H13NO
• Molecular Weight: 235.285
• Mol File: 63336-26-5.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Ethanone, 2-(1H-indol-3-yl)-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2-(1H-indol-3-yl)-1-phenyl-(63336-26-5)
• EPA Substance Registry System: Ethanone, 2-(1H-indol-3-yl)-1-phenyl-(63336-26-5)

Safety Data

• Hazardous Substances Data: 63336-26-5(Hazardous Substances Data)

Upstream product

• 120-72-9 indole 
• 13735-81-4 1-styrenyloxytrimethylsilane 
• 526-55-6 2-(3-indole)-ethanol 
• 17763-67-6 Phenyl triflate 
• 87-51-4 indole-3-acetic acid 
• 132922-37-3 2-(1H-indol-3-yl)-N-methoxy-N-methyl-acetamide 
• 100-58-3 phenylmagnesium bromide 
• 87-52-5 3-(Dimethylaminomethyl)indole 
• 100-52-7 benzaldehyde 

Downstream Products

• 129168-84-9 3-(2-Hydroxyimino-2-phenylethyl)indole 
• 46886-82-2 1-phenyl-2-(1H-indol-3-yl)ethan-1-ol 

Relevant articles and documents

Fe-catalyzed Fukuyama-type indole synthesis triggered by hydrogen atom transfer

Fe, Co, and Mn hydride-initiated radical olefin additions have enjoyed great success in modern synthesis, yet the extension of other hydrogen radicalophiles instead of olefins remains largely elusive. Herein, we report an efficient Fe-catalyzed intramolec

Ketone Synthesis by a Nickel-Catalyzed Dehydrogenative Cross-Coupling of Primary Alcohols

An intermolecular coupling of primary alcohols and organotriflates has been developed to provide ketones by the action of a Ni(0) catalyst. This oxidative transformation is proposed to occur by the union of three distinct catalytic cycles. Two competitive oxidation processes generate aldehyde in situ via hydrogen transfer oxidation or (pseudo)dehalogenation pathways. As aldehyde forms, a Ni-catalyzed carbonyl-Heck process enables formation of the key carbon-carbon bond. The utility of this rare alcohol to ketone transformation is demonstrated through the synthesis of diverse complex and bioactive molecules.

Acid-catalyzed highly diastereoselective and effective synthesis of 1,3-disubstituted tetrahydropyrano[3,4-b]indoles

We successfully explored for the first time that trifluoroacetic acid (TFA) can effectively catalyze the oxa-Pictet-Spengler reaction of secondary tryptophols and acetals to synthesize 1,3-disubstituted 1,3,4,9-tetrahydropyrano[3,4-b]indoles in high yield (up to >99%) and diastereoselectivity (>20:1). The secondary tryptophols were synthesized from indole-3-acetic acid. The one-pot synthesis of tetrahydropyrano[3,4-b]indoles was successfully developed from secondary tryptophols and in situ prepared acetals from aldehydes and trimethylorthoformate and thus the cost-efficiency of the protocol was effectively enhanced. Finally, the catalytic asymmetric synthesis of the 1,3-disubstituted tetrahydropyrano[3,4-b]indole was also demonstrated after enantioselective achievement of highly enantiopure secondary tryptophols.