473552-27-1

Basic information

• Product Name: Benzenemethanol, alpha-(aminomethyl)-4-fluoro-, (alphaS)- (9CI)
• Synonyms: Benzenemethanol, alpha-(aminomethyl)-4-fluoro-, (alphaS)- (9CI);Benzenemethanol, a-(aminomethyl)-4-fluoro-, (aS)-;Benzenemethanol, alfa-(aminomethyl)-4-fluoro-, (S)-;a-(aMinoMethyl)-4-fluoro-;(1S)-2-amino-1-(4-fluorophenyl)ethanol
• CAS NO: 473552-27-1
• Molecular Formula: C8H10FNO
• Molecular Weight: 155.1695032
• Product Categories: HALIDE
• Mol File: 473552-27-1.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzenemethanol, alpha-(aminomethyl)-4-fluoro-, (alphaS)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, alpha-(aminomethyl)-4-fluoro-, (alphaS)- (9CI)(473552-27-1)
• EPA Substance Registry System: Benzenemethanol, alpha-(aminomethyl)-4-fluoro-, (alphaS)- (9CI)(473552-27-1)

Safety Data

• Hazardous Substances Data: 473552-27-1(Hazardous Substances Data)

Usage

Description

Benzenemethanol, alpha-(aminomethyl)-4-fluoro-, (alphaS)(9CI) is a chemical compound characterized by the presence of a benzene ring, a hydroxyl group, an aminomethyl group, and a fluorine atom at the alpha position. This unique structure endows it with versatile properties, making it a valuable intermediate in various chemical reactions and processes.

Uses

Used in Organic Synthesis:
Benzenemethanol, alpha-(aminomethyl)-4-fluoro-, (alphaS)(9CI) is used as a key intermediate in organic synthesis for the development of new compounds and materials. Its unique structure allows for a wide range of chemical reactions, enabling the creation of diverse products with potential applications in various industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Benzenemethanol, alpha-(aminomethyl)-4-fluoro-, (alphaS)(9CI) is utilized as a building block for the synthesis of drug candidates. Its presence in the molecular structure can impart specific biological activities, making it a valuable component in the development of new medications with improved therapeutic properties.
Used in Chemical Processes:
Benzenemethanol, alpha-(aminomethyl)-4-fluoro-, (alphaS)(9CI) is also employed in various chemical processes, such as the production of specialty chemicals, agrochemicals, and other industrial chemicals. Its versatility and reactivity make it a valuable component in the synthesis of a wide range of chemical products.

Upstream product

• 17628-74-9 p-fluorophenylglyoxalmonoxime 
• 133721-87-6 2-(4-fluorophenyl)-2-hydroxyacetonitrile 
• 75-52-5 nitromethane 
• 459-57-4 4-fluorobenzaldehyde 
• 864539-93-5 tert-butyl [2-(4-fluorophenyl)-2-hydroxyethyl]carbamate 
• 456-00-8 2-amino-4'-fluoroacetophenone hydrochloride 
• 1029598-42-2 1-(4-fluorophenyl)-2-nitroethanol 
• 18511-62-1 4-fluorostyrene oxide 
• 403-29-2 2-bromo-4'-fluoroacetophenone 
• 1017172-13-2 2-[2-(4-fluoro-phenyl)-2-hydroxy-ethyl]-isoindole-1,3-dione 
• 82585-50-0 2-[2-(4-fluoro-phenyl)-2-oxo-ethyl]-isoindole-1,3-dione 
• 118887-70-0 2-azido-1-(4-fluoro-phenyl)-ethanone 
• 118888-01-0 rac-2-azido-1-(4-fluorophenyl)ethanol 
• 369-43-7 2-amino-1-(4-fluorophenyl)ethan-1-one 

Downstream Products

• 1426152-48-8 C₁₅H₁₃FN₄O₂S 
• 1426152-52-4 C₁₅H₁₁FN₄O₂S 
• 19338-43-3 5-(4-fluorophenyl)-1,3-oxazolidin-2-one 

Relevant articles and documents

Enantioselective Aminohydroxylation of Styrenyl Olefins Catalyzed by an Engineered Hemoprotein

Chiral 1,2-amino alcohols are widely represented in biologically active compounds from neurotransmitters to antivirals. While many synthetic methods have been developed for accessing amino alcohols, the direct aminohydroxylation of alkenes to unprotected, enantioenriched amino alcohols remains a challenge. Using directed evolution, we have engineered a hemoprotein biocatalyst based on a thermostable cytochrome c that directly transforms alkenes to amino alcohols with high enantioselectivity (up to 2500 TTN and 90 % ee) under anaerobic conditions with O-pivaloylhydroxylamine as an aminating reagent. The reaction is proposed to proceed via a reactive iron-nitrogen species generated in the enzyme active site, enabling tuning of the catalyst's activity and selectivity by protein engineering.

Novel morpholine scaffolds as selective dopamine (DA) D3 receptor antagonists

A new series of morpholine derivatives has been identified as selective DA D3 receptor antagonists; their in vitro profile and pharmacokinetic data are provided.

Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors

Protein arginine methyltransferases (PRMTs) play an important role in diverse biological processes. Among the nine known human PRMTs, PRMT3 has been implicated in ribosomal biosynthesis via asymmetric dimethylation of the 40S ribosomal protein S2 and in c