474-67-9 Usage
Description
Brassicasterol is a plant sterol that shares a similar structure with cholesterol. It is found in various dietary sources such as canola oil, rapeseed oil, marine algae, and shellfish. BRASSICASTEROL has been shown to inhibit sterol Δ24-reductase, an enzyme that plays a role in the mammalian cholesterol biosynthesis pathway.
Uses
Used in Cholesterol Biosynthesis Inhibition:
Brassicasterol is used as a cholesterol biosynthesis inhibitor for its ability to inhibit sterol Δ24-reductase, an enzyme involved in the mammalian cholesterol biosynthesis pathway. This application is significant in the study and potential treatment of conditions related to high cholesterol levels.
Used in Analytical Chemistry:
In the field of analytical chemistry, Brassicasterol is used as a standard for analyzing sterols from various samples, such as mussels, through thin layer chromatography. This application aids in the accurate identification and quantification of sterols in different biological samples.
Used in Pharmaceutical Industry:
Brassicasterol, due to its structural similarity with cholesterol, can be utilized in the pharmaceutical industry for the development of drugs targeting cholesterol-related conditions. Its role in inhibiting a key enzyme in cholesterol biosynthesis makes it a promising candidate for drug discovery and design.
Used in Nutritional Research:
As a plant sterol found in various dietary sources, Brassicasterol can be used in nutritional research to study the effects of plant sterols on human health, particularly in relation to cholesterol levels and cardiovascular health.
Used in Food Industry:
In the food industry, Brassicasterol can be used as an additive or a component in the development of functional foods that aim to lower cholesterol levels in consumers. Its presence in various oils and marine sources makes it a viable option for incorporation into health-conscious food products.
Biochem/physiol Actions
Brassicasterol is a plant sterol, structurally similar to cholesterol. Plant sterols compete with cholesterol and reduce the content of cholesterol incorporated into micelles thereby reducing its absorption. Brassicasterol reportedly decreases the progression of atherosclerosis. The level of brassicasterol in cerebrospinal fluid may be used as a prognostic factor for progression of Alzheimer′s disease.
Check Digit Verification of cas no
The CAS Registry Mumber 474-67-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,7 and 4 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 474-67:
(5*4)+(4*7)+(3*4)+(2*6)+(1*7)=79
79 % 10 = 9
So 474-67-9 is a valid CAS Registry Number.
474-67-9Relevant articles and documents
7-Dehydrocholesterol reductase activity is independent of cytochrome P450 reductase
Zou, Ling,Li, Li,Porter, Todd D.
experimental part, p. 435 - 438 (2012/04/23)
7-Dehydrocholesterol reductase (DHCR7) catalyzes the final step in cholesterol synthesis. The enzyme utilizes NADPH as a source of electrons and has been reported to require NADPH-cytochrome P450 reductase (POR) as its redox partner. To test this hypothes
Process for recovery of plant sterols from by-product of vegetable oil refining
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Page/Page column 5-6, (2008/06/13)
The process for recovery of plant sterols and tocopherols from deodorization distillates formed during chemical or physical refining of vegetable oils consists of the following steps: free fatty acids are removed from the deodorization distillate by vacuum distillation or by continuation solvent saponification, after the removal of free fatty acids, the received material is reacted with an aromatic carboxylic acid anhydride at a temperature of 50-150° C., under reduced pressure, after the treatment with anhydride, tocopherols are removed from the mixture, and crystalline free sterols are recovered from the distillation residue containing sterol esters, di- and triglycerides by transesterification.
A NEW SYNTHESIS OF BRASSICASTEROL
Khripach, V. A.,Zhabinskii, V. N.,Zhernosek, E. V.
, p. 74 - 77 (2007/10/02)
A new method has been developed for obtaining brassicasterol - the initial compound for the synthesis of the natural brassinosteroid epibrassinolide.
