4743-91-3Relevant articles and documents
Copper-catalyzed oxytrifluoromethylation of unactivated alkenes
Zhu, Rong,Buchwald, Stephen L.
, p. 12462 - 12465 (2012)
A mild, versatile, and convenient method for the efficient oxytrifluoromethylation of unactivated alkenes based on a copper-catalyzed oxidative difunctionalization strategy has been developed. This methodology provides access to a variety of classes of sy
Organocatalyzed asymmetric 1,4-addition of azlactones to α,β-unsaturated trichloromethyl ketones: Synthesis of α,α-disubstituted α-amino acid derivatives
Zhang, Jinlong,Liu, Xihong,Wu, Chongyang,Zhang, Panpan,Chen, Jianbo,Wang, Rui
supporting information, p. 7104 - 7108 (2015/01/16)
The first asymmetric 1,4-addition of azlactones to α,β-unsaturated trichloromethyl ketones catalyzed by cinchona alkaloid derived bifunctional thiourea catalysts was developed. A series of α,α-disubstituted α-amino acid derivatives bearing a quaternary stereocenter at the α-position were obtained in high yields with excellent diastereo- and enantioselectivities (up to -20:1 dr and 99% ee). In addition, the trichloromethyl moiety in these adducts was identified as a good leaving group.
α-Allylation of α-amino acids via 1,5-hydrogen atom transfer
Chowdhry, Muhammad I.,Horton, Peter N.,Hursthouse, Michael B.,Wood, Mark E.
scheme or table, p. 3400 - 3403 (2009/09/05)
A straightforward method for the radical-based α-allylation of proteinogenic α-amino acids is described in which the key step involves 1,5-hydrogen atom transfer from the C-4 position of an oxazolidin-5-one.
