474706-34-8

Basic information

• Product Name: 3-[4-(Methylthio)phenyl]-1H-pyrazole
• Synonyms: 3-[4-(Methylthio)phenyl]-1H-pyrazole;3-(4-methylsulfanylphenyl)-2H-pyrazole;3-[4-(methylthio)phenyl]-2H-pyrazole
• CAS NO: 474706-34-8
• Molecular Formula: C₁₀H₁₀N₂S
• Molecular Weight: 190.2648
• Mol File: 474706-34-8.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-[4-(Methylthio)phenyl]-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[4-(Methylthio)phenyl]-1H-pyrazole(474706-34-8)
• EPA Substance Registry System: 3-[4-(Methylthio)phenyl]-1H-pyrazole(474706-34-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 474706-34-8(Hazardous Substances Data)

Usage

Main properties

Chemical compound

Specific content

Also known as 4-(methylthio)phenyl-1H-pyrazol-3-amine
Contains a methylthio group on the phenyl ring
Used in synthesis of pharmaceuticals and agrochemicals
Potential building block for biologically active molecules and drugs

Upstream product

• 1778-09-2 4-(Methylthio)acetophenone 
• 98546-51-1 (4-thiomethoxyphenyl)boronic acid 
• 14521-80-3 3-bromo-1H-pyrazole 

Downstream Products

• 474706-37-1 4-Bromo-3-[4-(methylsulfanyl)phenyl)-1H-pyrazole 

Relevant articles and documents

Suzuki-miyaura cross-coupling of unprotected, nitrogen-rich heterocycles: Substrate scope and mechanistic investigation

The Suzuki-Miyaura cross-coupling of unprotected, nitrogen-rich heterocycles using precatalysts P1 or P2 is reported. The procedure allows for the reaction of variously substituted indazole, benzimidazole, pyrazole, indole, oxindole, and azaindole halides under mild conditions in good to excellent yields. Additionally, the mechanism behind the inhibitory effect of unprotected azoles on Pd-catalyzed cross-coupling reactions is described based on evidence gained through experimental, crystallographic, and theoretical investigations.