475086-46-5Relevant articles and documents
Mechanistic analysis of azine N-oxide direct arylation: Evidence for a critical role of acetate in the Pd(OAc)2 precatalyst
Sun, Ho-Yan,Gorelsky, Serge I.,Stuart, David R.,Campeau, Louis-Charles,Fagnou, Keith
supporting information; experimental part, p. 8180 - 8189 (2011/03/17)
Detailed mechanistic studies on the palladium-catalyzed direct arylation of pyridine N-oxides are presented. The order of each reaction component is determined to provide a general mechanistic picture. The C-H bond cleaving step is examined in further det
HETEROCYCLIC COMPOUND DERIVATIVES AND MEDICINES
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Page 23, (2010/02/05)
The present invention provides a compound which is useful as a PGI2 receptor agonist, and a pharmaceutical composition. The present invention is directed to a pharmaceutical composition comprising a compound represented by the following formula [1]: (R1 and R2 are the same or different and each represents optionally substituted aryl, Y represents N or CH, Z represents N or CH, A represents NH, NR5, O, S, or ethylene, R5 represents alkyl, D represents alkylene or alkenylene, E represents phenylene or single bond, G represents O, S, or CH2, R3 and R4 are the same or different and each represents hydrogen or alkyl, Q represents carboxy, alkoxycarbonyl, tetrazolyl, carbamoyl, or N-(alkylsulfonyl)carbamoyl), or a pharmaceutically acceptable salt thereof as an active ingredient.