475630-10-5Relevant articles and documents
Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay. 4. Structure-activity relationships of N-alkyl substituted pyrrole fused at the 7,8-positions
Kemnitzer, William,Drewe, John,Jiang, Songchun,Zhang, Hong,Crogan-Grundy, Candace,Labreque, Denis,Bubenick, Monica,Attardo, Giorgio,Denis, Real,Lamothe, Serge,Gourdeau, Henriette,Tseng, Ben,Kasibhatla, Shailaja,Sui, Xiong Cai
, p. 417 - 423 (2008/09/20)
In our continuing effort to discover and develop apoptosis inducing 4-aryl-4H-chromenes as novel anticancer agents, we explored the structure-activity relationship (SAR) of alkyl substituted pyrrole fused at the 7,8-positions. A methyl group substituted a