7556-37-8

Basic information

• Product Name: 1-Methyl-1H-indol-4-ol
• Synonyms: 1-Methyl-1H-indol-4-ol
• CAS NO: 7556-37-8
• Molecular Formula: C₉H₉NO
• Molecular Weight: 147.17386
• Mol File: 7556-37-8.mol
• Article Data: 10

Chemical Properties

• Melting Point: 90 °C
• Boiling Point: 316.8±15.0 °C(Predicted)
• Appearance: /
• Density: 1.15±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 10.07±0.40(Predicted)
• CAS DataBase Reference: 1-Methyl-1H-indol-4-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-1H-indol-4-ol(7556-37-8)
• EPA Substance Registry System: 1-Methyl-1H-indol-4-ol(7556-37-8)

Safety Data

• Hazardous Substances Data: 7556-37-8(Hazardous Substances Data)

Usage

General Description

1-Methyl-1H-indol-4-ol, also known by its Chemical Abstracts Service (CAS) number 15366-32-2, belongs to the indoles class of organic chemicals, which are compounds containing an indole moiety, which consists of a pyrrole ring fused to a benzene ring. It is a light yellow solid with a slight, sweet odor. 1-Methyl-1H-indol-4-ol has a wide application in the field of medicinal chemistry due to its versatile biological activities. However, like many chemicals, it needs to be handled with appropriate safety measures as it may cause skin, eye and respiratory irritation.

Upstream product

• 13523-93-8 4-(benzyloxy)-1-methyl-1H-indole 
• 7556-35-6 4-methoxy-1-methyl-1H-indole 
• 1393348-14-5 C₉H₁₀INO 
• 20289-26-3 4-benzyloxy-1H-indole 

Downstream Products

• 627501-90-0 2-Amino-3-cyano-4-(3-fluorophenyl)-7-methyl-4H-pyrrolo[2,3-h]chromene 
• 627501-40-0 2-Amino-4-(3-bromo-4-hydroxy-5-methoxyphenyl)-3-cyano-7-methyl-4H-pyrrolo[2,3-h]chromene 
• 627501-52-4 2-Amino-4-(4-acetoxy-3-bromo-5-methoxyphenyl)-3-cyano-7-methyl-4H-pyrrolo[2,3-h]chromene 
• 475630-10-5 2-amino-3-cyano-4-(3-methoxy-phenyl)-7-methyl-4H-pyrrolo[2,3-h]chromene 
• 898289-06-0 1-methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-indole 

Relevant articles and documents

Application of metallide/palladium compound catalytic reduction system in reaction of removing allyl groups and deuteration reaction

The invention discloses application of a metallide/palladium compound catalytic reduction system in reaction of removing allyl groups of a compound containing the allyl groups and deuteration reaction. The reaction comprises the following steps: under protection of nitrogen gas, suspending a palladium compound and a metallide in a solvent, stirring for 5 minutes, adding the compound containing theallyl groups, reacting for 0.5-36 hours at the temperature of minus 50-120 DEG C, adding ice water to stop reaction, regulating a pH value to 3.5 by using diluted hydrochloric acid, and carrying outsolvent extraction, drying by steaming and column-chromatography purification on reaction liquid to finish the reaction.

Pd-Catalyzed debenzylation and deallylation of ethers and esters with sodium hydride

Herein we demonstrate simply that the addition of Pd(OAc)2 as a promotor switches the reactivity of a commonly used base NaH to a nucleophilic reductant. The reactivity is engineered into a palladium-catalyzed reductive debenzylation and deallylation of aryl ethers and esters. This operationally simple, mild protocol displays a broad substrate scope and a broad spectrum of functional group tolerance (>50 examples) and high chemoselectivity toward aryl ethers over aliphatic structures. Moreover, the dual reactivity of NaH as a base and a reductant is demonstrated in efficient synthetic elaboration.

Scaffold hopping of sampangine: Discovery of potent antifungal lead compound against Aspergillus fumigatus and Cryptococcus neoformans

Discovery of novel antifungal agents against Aspergillus fumigatus and Cryptococcus neoformans remains a significant challenge in current antifungal therapy. Herein the antifungal natural product sampangine was used as the lead compound for novel antifungal drug discovery. A series of D-ring scaffold hopping derivatives were designed and synthesized to improve antifungal activity and water solubility. Among them, the thiophene derivative S2 showed broad-spectrum antifungal activity, particularly for Aspergillus fumigatus and Cryptococcus neoformans. Moreover, compound S2 also revealed better water solubility than sampangine, which represents a promising antifungal lead compound for further structural optimization.