477886-85-4

Basic information

• Product Name: 1,3,4-Oxadiazole, 2-[4-(trifluoromethyl)phenyl]-
• CAS NO: 477886-85-4
• Molecular Formula: C9H5F3N2O
• Molecular Weight: 214.147
• Mol File: 477886-85-4.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: 1,3,4-Oxadiazole, 2-[4-(trifluoromethyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3,4-Oxadiazole, 2-[4-(trifluoromethyl)phenyl]-(477886-85-4)
• EPA Substance Registry System: 1,3,4-Oxadiazole, 2-[4-(trifluoromethyl)phenyl]-(477886-85-4)

Safety Data

• Hazardous Substances Data: 477886-85-4(Hazardous Substances Data)

Usage

General Description

1,3,4-Oxadiazole, 2-[4-(trifluoromethyl)phenyl]- is a chemical compound with the molecular formula C9H5F3N2O. It is a white to yellow crystalline solid with a molecular weight of 208.1 g/mol. 1,3,4-Oxadiazole, 2-[4-(trifluoromethyl)phenyl]- is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It has also been studied for its potential applications in materials science, particularly as a building block for the construction of organic semiconductors and optoelectronic devices. Additionally, 1,3,4-Oxadiazole, 2-[4-(trifluoromethyl)phenyl]- has been investigated for its biological and pharmacological properties, with potential applications in the development of new drugs and therapeutic agents.

Upstream product

• 339-59-3 4-(trifluoromethyl)benzoic acid hydrazide 
• 1895-39-2 sodium chlorodifluoroacetate 
• 455-13-0 4-Iodobenzotrifluoride 
• 68-12-2 N,N-dimethyl-formamide 
• 455-24-3 4-trifluoromethylbenzoic acid 
• 2967-66-0 methyl 4-(trifluoromethyl)benzoate 
• 122-51-0 orthoformic acid triethyl ester 
• 149-73-5 trimethyl orthoformate 
• 43100-38-5 4-tert-butylbenzoic acid hydrazide 

Downstream Products

• 1236115-27-7 methyl 5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazole-2-carboxylate 
• 1350920-04-5 (E)-2-(3,4-dimethoxystyryl)-5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazole 
• 1350920-00-1 (E)-2-(2-(biphenyl-4-yl)vinyl)-5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazole 
• 1350919-95-7 2-[(E)-2-phenylvinyl]-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazole 
• 1374348-21-6 2-(naphthalen-1-ylethynyl)-5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazole 
• 724435-75-0 2-(pyridin-3-yl)-5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazole 

Relevant articles and documents

[4u202f+u202f1] Cyclization of benzohydrazide and ClCF2COONa towards 1,3,4-oxadiazoles and 1,3,4-oxadiazoles-d5

A facile synthesis of 1,3,4-oxadiazoles and 1,3,4-oxadiazoles-d5 via [4 + 1] cyclization of ClCF2COONa with non-amine compounds containing amino groups is developed. Of note, this is the first time that halofluorinated compounds are used as C1 synthon to construct deuterated nitrogen-heterocyclic compounds. The current protocol features simple operation, readily accessible raw materials, wide substrate scope and valuable products

Functionalization of 1,3,4-Oxadiazoles and 1,2,4-Triazoles via Selective Zincation or Magnesiation Using 2,2,6,6-Tetramethylpiperidyl Bases

We report the metalation of the 1,3,4-oxadiazole and 1,2,4-triazole scaffolds via regioselective zincation or magnesiation using the TMP bases (TMP = 2,2,6,6-tetramethylpiperidyl) TMP2Zn·2LiCl, TMP2Zn·2MgCl2·2LiCl, TMPMgCl

Method for one-step construction of 2-(4-trifluoromethyl phenyl)-1,3,4-oxadiazole by taking DMF (dimethyl formamide) as carbon source

The invention discloses a method for one-step construction of 2-(4-trifluoromethyl phenyl)-1,3,4-oxadiazole by taking DMF (dimethyl formamide) as a carbon source. In the method, p-trifluoromethyl benzoyl hydrazine is used as a reaction raw material, and t