43100-38-5

Basic information

• Product Name: 4-tert-Butylbenzhydrazide
• Synonyms: Benzoic acid, 4-(1,1-dimethylethyl)-, hydrazide;p-tert-butylbenzohydrazide;LABOTEST-BB LT00454438;BUTTPARK 44\03-79;AKOS BBS-00004509;4-TERT-BUTYLBENZHYRAZIDE;4-TERT-BUTYLBENZOHYDRAZIDE;4-TERT-BUTYLBENZOIC ACID HYDRAZIDE
• CAS NO: 43100-38-5
• Molecular Formula: C₁₁H₁₆N₂O
• Molecular Weight: 192.26
• EINECS: 256-090-9
• Product Categories: Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes;Benzenes;Carbonyl Compounds;Hydrazides;Organic Building Blocks;Building Blocks;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks
• Mol File: 43100-38-5.mol
• Article Data: 41

Chemical Properties

• Melting Point: 120-127 °C(lit.)
• Appearance: white to light beige crystalline powder
• Density: 1.046 g/cm³
• Refractive Index: 1.534
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• Solubility: soluble in Methanol
• PKA: 12.82±0.10(Predicted)
• BRN: 1104663
• CAS DataBase Reference: 4-tert-Butylbenzhydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-tert-Butylbenzhydrazide(43100-38-5)
• EPA Substance Registry System: 4-tert-Butylbenzhydrazide(43100-38-5)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 24/25-36/37-26-37
• WGK Germany: 3
• TSCA: Yes
• HazardClass: IRRITANT
• Hazardous Substances Data: 43100-38-5(Hazardous Substances Data)

Usage

Uses

4-tert-Butylbenzoic hydrazide was used in the synthesis of 2-(2-methylphenyl)-5-(4-tert-butylphenyl)-1,3,4-oxadiazole.

InChI:InChI=1/C11H16N2O/c1-11(2,3)9-6-4-8(5-7-9)10(14)13-12/h4-7H,12H2,1-3H3,(H,13,14)

Upstream product

• 26537-19-9 methyl 4-tert-butylbenzoate 
• 5406-57-5 ethyl 4-tert-butylbenzoate 
• 1710-98-1 p-tert-butyl benzoyl chloride 
• 109-02-4 4-methyl-morpholine 
• 98-73-7 4-(1,1-dimethylethyl)benzoic acid 
• 543-27-1 isobutyl chloroformate 
• 6282-27-5 propyl 4-tert-butylbenzoate 
• 939-97-9 4-tert-Butylbenzaldehyde 

Downstream Products

• 116324-88-0 4-tert-Butyl-benzoic acid [1-(3-hydroxy-5-hydroxymethyl-2-methyl-pyridin-4-yl)-meth-(E)-ylidene]-hydrazide 
• 82859-75-4 (E)-4-(tert-butyl)-N'-(2-hydroxybenzylidene)benzohydrazide 
• 68758-85-0 p-(tert-butyl)[(2-hydroxy-1-naphthyl)methylene]benzohydrazide 
• 175791-95-4 5-Iodoisophthalic acid bis[2-(4-tert-butylbenzoyl)hydrazide] 
• 109352-39-8 4-tert-Butyl-benzoic acid [1-pyridin-2-yl-meth-(E)-ylidene]-hydrazide 
• 109352-37-6 4-tert-butyl-N′-(1-(pyridin-2-yl)ethylidene)benzohydrazide 
• 1004679-42-8 1-(4'-t-butylbenzoyl)-2-(2,5-dimethylbenzoyl) hydrazine 
• 754214-36-3 2-(chloromethyl)-5-(4-t-butylphenyl)-1,3,4-oxadiazole 
• 866755-70-6 (2R,3R,4R,5R)-2,5-Bis-((E)-3-bromo-allyloxy)-6-[N'-(4-tert-butyl-benzoyl)-hydrazino]-3,4-dihydroxy-6-oxo-hexanoic acid ((1S,2R)-2-hydroxy-indan-1-yl)-amide 

Relevant articles and documents

Physicochemical properties of 4-tert-butylbenzoic acid N′,N′- dialkylhydrazides

Properties of hydrazides of 4-tert-butylbenzoic acid, important for their application in extraction technology, have been studied: solubility, acid-base properties, distribution between immiscible liquids, and hydrolytic stability. pH ranges of existence

Design, synthesis, and biological evaluation of phenyloxadiazole derivatives as potential antifungal agents against phytopathogenic fungi

Abstract: A novel series of picarbutrazox-inspired oxadiazole hybrids was synthesized and the derivatives’ biological activity against phytopathogenic fungi was investigated. The molecules were designed by retaining the active fragment of tetrazolyl phenyloxime ether of lead compound picarbutrazox, while introducing the potentially active oxadiazole-derived fragment. Bioassay results revealed that some of the title compounds showed potent in vivo antifungal activities to control cucumber downy mildew. Therefore, this novel oxadiazole phenyloxadiazole derivative can be used as a potential antifungal agent to control cucumber downy mildew and other phytopathogenic fungi for crop protection. Graphic abstract: [Figure not available: see fulltext.].

Design, Synthesis, and Pharmacological Evaluation of First-in-Class Multitarget N-Acylhydrazone Derivatives as Selective HDAC6/8 and PI3Kα Inhibitors

Targeting histone deacetylases (HDACs) and phosphatidylinositol 3-kinases (PI3Ks) is a very promising approach for cancer treatment. This manuscript describes the design, synthesis, in vitro pharmacological profile, and molecular modeling of a novel class of N-acylhydrazone (NAH) derivatives that act as HDAC6/8 and PI3Kα dual inhibitors. The surprising selectivity for PI3Kα may be related to differences in the conformation in the active site. Cellular studies showed that these compounds act in HDAC6 inhibition and the PI3/K/AKT/mTOR pathway. The compounds that are selective for inhibition of HDAC6/8 and inhibit PI3Kα show potential for the treatment of cancer.