4792-29-4Relevant articles and documents
Gallium trihalide catalyzed sequential addition of two different carbon nucleophiles to esters by using silyl cyanide and ketene silyl acetals
Inamoto, Yoshihiro,Kaga, Yuta,Nishimoto, Yoshihiro,Yasuda, Makoto,Baba, Akio
supporting information, p. 11664 - 11668 (2014/10/15)
A sequential addition of silyl cyanide and ketene silyl acetals to esters was achieved by a gallium trihalide catalyst to produce β-cyano-β- siloxy esters. This is the first example of the sequential addition of two different carbon nucleophiles to esters. The employment of lactones provided α,α-disubstituted cyclic ethers with a cyano group and an ester moiety. A variety of esters and lactones are applicable to this reaction system.
AN IMPROVED PROCESS FOR THE PREPARATION OF 5 - CARBOXYPHTHALIDE
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Page/Page column 8-9, (2008/06/13)
The invention disclosed in this applications relates to an improved process for the preparation of 5-carboxy phthalide useful as an intermediate for the preparation of citlopram which comprises adding terephthalic acid to Chloromethyl chlorosulphate , heating , adding water portion wise filtering , centrifuging and washing the resultant product with water.
INTERMEDIATES FOR THE PREPARATION OF CITALOPRAM AND ESCITALOPRAM
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Page 21, (2010/02/08)
Methods for manufacture of 5-alkoxycarbonylphthtalides are disclosed. The 5-alkoxycarbonylphthtalides are useful in syntheses of the well-known antidepresssants citalopram and escitalopram.