4812-45-7

Basic information

• Product Name: 3-CHLORO-5-NITRO-1H-INDAZOLE
• Synonyms: 3-CHLORO-5-NITRO-1H-INDAZOLE;3-chloro-5-nitro-indazol;3-chloro-5-nitroindazole;3-Chloro-5-nitro-1H-indazole ,97%;1H-INDAZOLE,3-CHLORO-5-NITRO
• CAS NO: 4812-45-7
• Molecular Formula: C7H4ClN3O2
• Molecular Weight: 197.58
• EINECS: 225-380-7
• Mol File: 4812-45-7.mol
• Article Data: 10

Chemical Properties

• Melting Point: 218-220
• Boiling Point: 234.7 °C at 760 mmHg
• Flash Point: 95.7 °C
• Appearance: /
• Density: 1.661g/cm³
• Vapor Pressure: 0.0522mmHg at 25°C
• Refractive Index: 1.742
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 9?+-.0.40(Predicted)
• CAS DataBase Reference: 3-CHLORO-5-NITRO-1H-INDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-5-NITRO-1H-INDAZOLE(4812-45-7)
• EPA Substance Registry System: 3-CHLORO-5-NITRO-1H-INDAZOLE(4812-45-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 4812-45-7(Hazardous Substances Data)

Usage

Chemical Properties

Yellow solid

InChI:InChI=1/C7H4ClN3O2/c8-7-5-3-4(11(12)13)1-2-6(5)9-10-7/h1-3H,(H,9,10)

Upstream product

• 5401-94-5 5-nitroindazole 
• 61346-19-8 5-nitroindazolin-3-one 
• 7719-12-2 phosphorus trichloride 
• 128-09-6 N-chloro-succinimide 
• 99-52-5 2-methyl-4-nitro-benzenamine 

Downstream Products

• 105126-48-5 3-Chloro-5-nitro-indazole-1-carboxylic acid (4-chloro-phenyl)-amide 
• 141278-23-1 3-Chlor-1-(2,3-epoxypropyl)-5-nitroindazol 
• 141278-22-0 3-Chlor-1-(3-chlor-2-hydroxypropyl)-5-nitroindazol 
• 41330-49-8 5-amino-3-chloro-1H-indazole 
• 1026472-85-4 N⁷-benzyl-3-chloro-1H-indazole-5,7-diamine 
• 1025986-76-8 benzyl-(3-chloro-5-nitro-1H-indazol-7-yl)-amine 
• 1026557-91-4 3-chloro-N⁷-phenethyl-1H-indazole-5,7-diamine 
• 1026977-28-5 (3-chloro-5-nitro-1H-indazol-7-yl)-phenethyl-amine 
• 647853-43-8 3-bromo-N-(3-chloro-7-isobutylamino-1H-indazol-5-yl)-benzenesulfonamide 

Relevant articles and documents

THERAPEUTIC INDAZOLES

The invention provides compounds of formula (I): and salts thereof wherein R1-R5 have any of the meanings described in the specification. The compounds are useful for treating bacterial infections (e.g. tuberculosis).

Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor

The present invention relates to the antagonism of the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or treatment of eating disorders, weight gain, obesity, abnormalities in reproduction and sexual behavior, thyroid hormone secretion, diuresis and water/electrolyte homeostasis, sensory processing, memory, sleeping, arousal, anxiety, depression, seizures, neurodegeneration and psychiatric disorders.

Structure-Based Design, Synthesis, and Antimicrobial Activity of Indazole-Derived SAH/MTA Nucleosidase Inhibitors

The structure-based design, synthesis, and biological activity of a novel indazole-containing inhibitor series for S-adenosyl homocysteine/methylthioadenosine (SAH/MTA) nucleosidase are described. Use of 5-aminoindazole as the core scaffold provided a structure-guided series of low nanomolar inhibitors with broad-spectrum antimicrobial activity. The implementation of structure-based methodologies provided a 6000-fold increase in potency over a short timeline (several months) and an economy of synthesized compounds.