61346-19-8

Basic information

• Product Name: 1,2-DIHYDRO-5-NITROINDAZOL-3-ONE
• Synonyms: 3-HYDROXY-5-NITRO (1H)INDAZOLE;5-NITRO-1,2-DIHYDRO-3H-INDAZOL-3-ONE;5-NITRO-3-INDAZOLINONE;1,2-DIHYDRO-5-NITROINDAZOL-3-ONE;2,3-DIHYDRO-5-NITRO-1H-INDAZOL-3-ONE;1,2-Dihydro-5-nitro-3H-indazol-3-one;3-HYDROXY-5-NITROINDAZOLE;5-Nitro-1H-indazol-3(2H)-one
• CAS NO: 61346-19-8
• Molecular Formula: C₇H₅N₃O₃
• Molecular Weight: 179.13
• EINECS: 262-728-7
• Product Categories: Indoles and derivatives
• Mol File: 61346-19-8.mol
• Article Data: 2

Chemical Properties

• Melting Point: 280-282°C
• Boiling Point: 297.1 °C at 760 mmHg
• Flash Point: 133.5 °C
• Appearance: /
• Density: 1.506 g/cm³
• Vapor Pressure: 0.00137mmHg at 25°C
• Refractive Index: 1.634
• Storage Temp.: 2-8°C
• PKA: 10.20±0.20(Predicted)
• CAS DataBase Reference: 1,2-DIHYDRO-5-NITROINDAZOL-3-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-DIHYDRO-5-NITROINDAZOL-3-ONE(61346-19-8)
• EPA Substance Registry System: 1,2-DIHYDRO-5-NITROINDAZOL-3-ONE(61346-19-8)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 61346-19-8(Hazardous Substances Data)

Usage

General Description

1,2-Dihydro-5-nitroindazol-3-one is a chemical compound with the molecular formula C8H6N4O3. It is a nitro-substituted heterocyclic compound that is often used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 1,2-DIHYDRO-5-NITROINDAZOL-3-ONE is known for its potential as a mutagenic compound and is used in scientific research as a tool for studying the effects of certain chemical reactions. It is a yellow crystalline solid that is insoluble in water, but soluble in most organic solvents. 1,2-Dihydro-5-nitroindazol-3-one can be synthesized through various methods, including the nitration of indazole derivatives or the reduction of nitroindazole compounds. Its structure and properties make it an important building block for the synthesis of various organic compounds.

InChI:InChI=1/C7H5N3O3/c11-7-5-3-4(10(12)13)1-2-6(5)8-9-7/h1-3H,(H2,8,9,11)

Upstream product

• 16588-17-3 ethyl ester of 2-chloro-5-nitrobenzoic acid 
• 185556-56-3 2-hydrazino-5-nitro-benzoic acid 
• 2516-96-3 2-chloro-5-nitrobenzoic acid 

Downstream Products

• 178160-26-4 2-(2-Fluorobenzyl)-5-nitro-1,2-dihydro-3H-indazol-3-one 
• 178160-22-0 ethyl 3-hydroxy-5-nitro-1H-indazole-1-carboxylate 
• 2215-59-0 1-Benzyl-5-nitro-1H-indazol-3-ol 
• 178160-25-3 2-Benzyl-5-nitro-1,2-dihydro-3H-indazol-3-one 
• 178160-23-1 1-(4-Methoxybenzyl)-5-nitro-1H-indazol-3-ol 
• 178160-21-9 1-(2-Benzyloxybenzyl)-5-nitro-1H-indazol-3-ol 
• 4812-45-7 3-chloro-5-nitro-1H-indazole 

Relevant articles and documents

NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS

This invention relates to novel compounds which are inhibitors of acyl coenzymeA: diacylglycerol acyltransferase 1 (DGAT-1), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the prevention or treatment of diseases related to DGAT-1 dysfunction or where modulation of DGAT-1 activity may have therapeutic benefit including but not limited to obesity, obesity related disorders, hypertriglyceridemia, hyperlipoproteinemia, chylomicronemia, dyslipidemia, non-alcoholic steatohepatitis, diabetes, insulin resistance, metabolic syndrome, hepatitis C virus infection and acne or other skin disorders.