4896-75-7 Usage
Description
GLYCINE-2,2-D2, also known as Glycine-d2, is a labeled analogue of Glycine (G615990), which is a non-essential amino acid crucial for human development. It serves as an inhibitory neurotransmitter in the spinal cord and acts as an allosteric regulator of NMDA receptors.
Uses
Used in Pharmaceutical Industry:
GLYCINE-2,2-D2 is used as a labeled analogue for [application reason] in the pharmaceutical industry. It is particularly useful in research and development, as well as in the synthesis of various pharmaceutical compounds.
Used in Neuroscience Research:
GLYCINE-2,2-D2 is used as a research tool for studying the role of Glycine in the central nervous system, particularly as an inhibitory neurotransmitter in the spinal cord and its regulation of NMDA receptors.
Used in Diagnostic Applications:
GLYCINE-2,2-D2 is used as a diagnostic marker in the detection and monitoring of various neurological conditions and disorders related to neurotransmitter imbalances.
Used in Drug Development:
GLYCINE-2,2-D2 is used as a key component in the development of new drugs targeting the Glycine receptor system, which may have potential therapeutic applications in treating neurological and psychiatric disorders.
Used in Metabolic Studies:
GLYCINE-2,2-D2 is used as a tracer in metabolic studies to investigate the role of Glycine in various metabolic pathways and its impact on overall cellular function and homeostasis.
Check Digit Verification of cas no
The CAS Registry Mumber 4896-75-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,8,9 and 6 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 4896-75:
(6*4)+(5*8)+(4*9)+(3*6)+(2*7)+(1*5)=137
137 % 10 = 7
So 4896-75-7 is a valid CAS Registry Number.
4896-75-7Relevant articles and documents
Neelakantan et al.
, p. 275 (1963)
Synthesis methods of deuterine, hippuric acid-L-menthol ester (2,2-D2) and intermediates thereof
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Paragraph 0047; 0054-0055; 0058, (2018/10/26)
The invention discloses synthesis methods of deuterine, hippuric acid-L-menthol ester (2,2-D2) and intermediates thereof, wherein the synthesis method includes the steps: (1) carrying out a reaction of glycine with a deuterium aqueous solution of alkali metal deuterium oxide under the action of pyridoxal or salts thereof, to obtain a deuterated reaction solution; and (2) recycling a part of deuterium water from the deuterated reaction solution obtained in the step (1) through reduced pressure distillation, then adding water and benzoyl chloride, carrying out an amidation reaction, and after the end of the reaction, posttreating to obtain hippuric acid (2,2-D2). The raw materials and reagents used in the synthesis method are cheap and easy to obtain, and the operation is simple; the purityand the deuterium abundance of the obtained deuterated reagents are high.
Measurement of biosynthesis and breakdown rates of biological molecules that are inaccessible or not easily accessible to direct sampling, non-invasively, by label incorporation into metabolic derivatives and catabolitic products
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Page 4, (2008/06/13)
Methods of determining rate of biosynthesis or breakdown of biological molecules from metabolic derivatives and catabolic products are disclosed herein. In particular, methods of measuring the rates of biosynthesis and breakdown of biological molecules inaccessible or not easily accessible to direct sampling by sampling metabolic derivatives and catabolic products in accessible biological samples are disclosed herein.