42492-65-9 Usage
Description
GLYCINE-2,2-D2-N-T-BOC, also known as N-[(1,1-Dimethylethoxy)carbonyl]glycine-2,2-d2, is a deuterated amino acid derivative with a tert-butyloxycarbonyl (Boc) protecting group. It is a stable isotope-labeled compound that can be used as a reagent in various applications, particularly in the identification and study of proteins and peptides.
Uses
Used in Pharmaceutical Research:
GLYCINE-2,2-D2-N-T-BOC is used as a reagent for the identification of ERα17p, a peptide that reproduces the hinge region of the estrogen receptor α. This peptide has pharmacological effects in breast cancer cells, making it a valuable target for the development of new therapeutic agents.
Used in Biochemical Studies:
The deuterated nature of GLYCINE-2,2-D2-N-T-BOC allows it to be used in biochemical studies, where it can help in the investigation of protein structure, function, and interactions. The presence of deuterium isotopes can provide insights into the dynamics and stability of proteins and peptides, as well as their interactions with other biomolecules.
Used in Drug Development:
GLYCINE-2,2-D2-N-T-BOC can be employed in the development of new drugs targeting the estrogen receptor α or other related proteins. Its use as a reagent in the identification of ERα17p can aid in the design and synthesis of novel compounds with potential therapeutic effects in breast cancer and other diseases.
Used in Analytical Chemistry:
The stable isotope labeling of GLYCINE-2,2-D2-N-T-BOC makes it suitable for use in analytical chemistry techniques, such as mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy. These techniques can be employed to study the properties and behavior of proteins and peptides, as well as to monitor the progress of chemical reactions involving these compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 42492-65-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,2,4,9 and 2 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 42492-65:
(7*4)+(6*2)+(5*4)+(4*9)+(3*2)+(2*6)+(1*5)=119
119 % 10 = 9
So 42492-65-9 is a valid CAS Registry Number.
42492-65-9Relevant articles and documents
Cation dependence of chloride ion complexation by open-chained receptor molecules in chloroform solution
Pajewski, Robert,Ferdani, Riccardo,Pajewska, Jolanta,Li, Ruiqiong,Gokel, George W.
, p. 18281 - 18295 (2007/10/03)
Seventeen peptides, most having the sequence GGGPGGG, but differing in the C- and N-terminal ends, have been studied as anion-complexing agents. These relatively simple, open-chained peptide systems interact with both chloride and the associated cation. Changes in the N- and C-terminal side chains appear to make little difference in the efficacy of binding. NMR studies suggest that the primary interactions involve amide NH contacts with the chloride anion, and CD spectral analyses suggest a concomitant conformational change upon binding. Changes in binding constants, which are expected in different solvents, also suggest selective solvent interactions with the unbound host that helps to preorganize the open-chained peptide system. Significant differences are apparent in complexation strengths when the heptapeptide chain is shortened or lengthened or when the relative position of proline within the heptapeptide is varied.
