492456-52-7

Basic information

• Product Name: 3-Quinolinecarbonitrile, 4-hydroxy-7-Methoxy-6-nitro-
• Synonyms: 3-Quinolinecarbonitrile, 4-hydroxy-7-Methoxy-6-nitro-;4-hydroxy-7-Methoxy-6-nitroquinoline-3-carbonitrile
• CAS NO: 492456-52-7
• Molecular Formula: C₁₁H₇N₃O₄
• Molecular Weight: 245.19098
• Mol File: 492456-52-7.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 450.829°C at 760 mmHg
• Flash Point: 226.453°C
• Appearance: /
• Density: 1.511g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.647
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-Quinolinecarbonitrile, 4-hydroxy-7-Methoxy-6-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Quinolinecarbonitrile, 4-hydroxy-7-Methoxy-6-nitro-(492456-52-7)
• EPA Substance Registry System: 3-Quinolinecarbonitrile, 4-hydroxy-7-Methoxy-6-nitro-(492456-52-7)

Safety Data

• Hazardous Substances Data: 492456-52-7(Hazardous Substances Data)

Usage

Description

3-Quinolinecarbonitrile, 4-hydroxy-7-methoxy-6-nitrois a quinoline derivative with the molecular formula C11H8N2O4. It features a cyano group at the 3-position and hydroxy, methoxy, and nitro groups at the 4-, 7-, and 6-positions, respectively. This chemical compound is known for its potential biological activity and is commonly used in pharmaceutical and medicinal research. Its unique structure and properties make it a promising candidate for the development of new drugs and therapies, as well as a building block in the synthesis of various organic compounds.

Uses

Used in Pharmaceutical and Medicinal Research:
3-Quinolinecarbonitrile, 4-hydroxy-7-methoxy-6-nitrois used as a pharmaceutical and medicinal research compound for its potential biological activity. Its unique structure and properties make it a valuable candidate for the development of new drugs and therapies.
Used in Organic Synthesis:
3-Quinolinecarbonitrile, 4-hydroxy-7-methoxy-6-nitrois also used as a building block in the synthesis of various organic compounds, contributing to the creation of a wide range of chemical products.

InChI:InChI=1/C11H7N3O4/c1-18-10-3-8-7(2-9(10)14(16)17)11(15)6(4-12)5-13-8/h2-3,5H,1H3,(H,13,15)

Upstream product

• 501684-26-0 (E)-2-Cyano-3-(3-methoxy-4-nitro-phenylamino)-acrylic acid ethyl ester 
• 16292-88-9 3-methoxy-4-nitroanilin 
• 536-90-3 m-Anisidine 
• 19861-62-2 2,4-dichloro-5-nitrobenzoic acid 
• 90564-41-3 2,4-dimethoxy-5-nitrobenzoic acid 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 71083-64-2 1,4-dihydro-7-methoxy-4-oxo-quinoline-3-carbonitrile 
• 7440-44-0 pyrographite 

Downstream Products

• 214470-33-4 4-chloro-7-methoxy-6-nitro-quinoline-3-carbonitrile 
• 214484-03-4 6-amino-4-[(3-bromophenyl)amino]-7-methoxy-quinoline-3-carbonitrile 
• 214485-60-6 6-amino-4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinoline-3-carbonitrile 
• 501684-27-1 7-(3-chloro-propoxy)-4-hydroxy-6-nitroquinoline-3-carbonitrile 
• 501684-29-3 4-(3-chloro-4-fluoro-phenylamino)-7-(3-chloro-propoxy)-6-nitro-quinoline-3-carbonitrile 
• 501684-31-7 6-amino-4-(3-chloro-4-fluoro-phenylamino)-7-(3-morpholin-4-yl-propoxy)-quinoline-3-carbonitrile 
• 501684-30-6 4-(3-chloro-4-fluoro-phenylamino)-7-(3-morpholin-4-yl-propoxy)-6-nitro-quinoline-3-carbonitrile 
• 214485-59-3 4-(3-Chloro-4-fluoro-phenylamino)-7-methoxy-6-nitro-quinoline-3-carbonitrile 
• 214485-38-8 N-{4-[(3-bromo-4-fluorophenyl)amino]-3-cyano-7-methoxy-6-quinolinyl}-4-morpholino-2-butenamide 

Relevant articles and documents

4-quinazoline amine derivatives and their use

A 4-quinazoline amine derivative as represented by formula (1), a pharmaceutical composition comprising the derivative, and an application thereof in preparing medicine for curing cancer. The cancer is a drug-resistant cancer, preferably a cancer resisting an EGFR reversible inhibitor, and more preferably, a cancer resisting gefitinib, erlotinib or lapatinib; alternatively, the cancer carries EGFR mutation.

USE OF CYANOQUINOLINES FOR TREATING OR INHIBITING COLONIC POLYPS

This invention provides a method of treating or inhibiting colonic polyps which comprises providing a compound of formula (1); wherein R1, R2, R3, R4, X, Y, and n are defined hereinbefore, or a pharmaceutically acceptable salt thereof.

TRICYCLIC PROTEIN KINASE INHIBITORS

This invention provides compounds of Formula (I), where A'', Z, X and n are defined herein, or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of polycystic kidney disease.