4926-18-5

Basic information

• Product Name: 5-methyl[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
• CAS NO: 4926-18-5
• Molecular Formula: C₇H₇N₃O
• Molecular Weight: 149.15
• Mol File: 4926-18-5.mol
• Article Data: 3

Chemical Properties

• Density: 1.42g/cm³
• Refractive Index: 1.699
• CAS DataBase Reference: 5-methyl[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-methyl[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one(4926-18-5)
• EPA Substance Registry System: 5-methyl[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one(4926-18-5)

Safety Data

• Hazardous Substances Data: 4926-18-5(Hazardous Substances Data)

Upstream product

• 18368-63-3 6-chloro-2-picoline 
• 5315-24-2 1-(6-methylpyridin-2-yl)hydrazine 

Downstream Products

• 1613149-95-3 C₂₈H₃₀ClN₃O₁₀ 

Relevant articles and documents

The Base-Promoted Annulation of 2-Hydrazinyl Pyridine and CO2 toward Triazolones

A base-promoted annulation of 2-hydrazinyl pyridine and atmospheric pressure of CO2 has been developed in the presence of silane as reducing reagent, affording a series of triazolones in moderate to excellent yields. CO2 served as a carbonyl source in this transfomation. Moreover, benzamidrazones also worked well under this procedure. Thus, it represents a green, sustainable and straightforward pathway to access triazolone frameworks. (Figure presented.).

Antidepressant agent

2-[3-[4-[3-(Trifluoromethyl)phenyl]-1-piperazinyl]propyl]-1,2,4-triazolo[4,3-a]pyridin-3(2H)-one and its pharmaceutically acceptable acid addition salts are antidepressant agents.