494210-61-6

Basic information

• Product Name: 2H-Thiopyran-4-carboxaldehyde, tetrahydro-, 1,1-dioxide
• Synonyms: 2H-Thiopyran-4-carboxaldehyde, tetrahydro-, 1,1-dioxide;tetrahydro-2H-thiopyran-4-carbaldehyde 1,1-dioxide
• CAS NO: 494210-61-6
• Molecular Formula: C₆H₁₀O₃S
• Molecular Weight: 162.2068
• Mol File: 494210-61-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 361.6±35.0 °C(Predicted)
• Appearance: /
• Density: 1.356±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2H-Thiopyran-4-carboxaldehyde, tetrahydro-, 1,1-dioxide(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Thiopyran-4-carboxaldehyde, tetrahydro-, 1,1-dioxide(494210-61-6)
• EPA Substance Registry System: 2H-Thiopyran-4-carboxaldehyde, tetrahydro-, 1,1-dioxide(494210-61-6)

Safety Data

• Hazardous Substances Data: 494210-61-6(Hazardous Substances Data)

Usage

General Description

2H-Thiopyran-4-carboxaldehyde, tetrahydro-, 1,1-dioxide, also known as tetrahydrothiopyran-4-carboxaldehyde-1,1-dioxide, is a chemical compound with the molecular formula C5H8O3S. It is a heterocyclic compound that contains both oxygen and sulfur atoms in its five-membered ring structure. This chemical is primarily used as a building block for the synthesis of various organic compounds, including pharmaceuticals and agrochemicals. Its unique structure and reactivity make it useful in organic synthesis as a key intermediate in the production of other valuable chemical products. Additionally, its properties make it a useful tool for researchers and scientists working in the fields of chemistry and pharmacology.

Upstream product

• 50675-19-9 4-thianylcarbaldehyde 
• 473254-28-3 (1,1-dioxo-hexahydro-1-thiopyran-4-yl)-methanol 
• 64096-87-3 1,1-dioxo-hexahydro-1λ⁶-thiopyran-4-carboxylic acid 

Downstream Products

• 1174540-28-3 2-((R)-(1-(1,1-dioxohexahydro-1λ6-thiopyran-4-yl)methylamino)ethyl)-3-(4-chlorophenyl)pyrido[2,3d]pyrimidin-4(3H)-one 
• 1174540-21-6 (R)-2-(N-1-(3-(4-chlorophenyl)pyrido[2,3-d]pyrimidin-4(3H)-one)-N-(1,1-dioxohexahydro-1λ6-thiopyran-4-yl)methyl)-2-(3-fluoro-4-(trifluoromethyl)phenyl)acetamide 
• 1262797-01-2 C₃₀H₂₇ClF₄N₄O₄S 
• 1360889-96-8 C₂₅H₂₆N₄O₂S 
• 1272655-73-8 methyl [(1S)-2-methyl-1-({(2S)-2-[4-(4′-{2-[2-((2S)-3-methyl-2-{[(methyloxy)carbonyl]amino}butanoyl)-8,8-dioxido-8-thia-2-azaspiro[4.5]dec-3-yl]-1H-imidazol-4-yl}-4-biphenylyl)-1Himidazol-2-yl]-1-pyrrolidinyl}carbonyl)propyl]carbamate 
• 1272655-75-0 methyl N-[(2S)-1-[3-({2-[4-(4-{2-[(2S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl}phenyl)phenyl]-2-oxoethyl}carbamoyl)-8,8-dioxido-8-thia-2-azaspiro[4.5]decan-2-yl]-3-methyl-1-oxobutan-2-yl]carbamate 

Relevant articles and documents

Nickel-Catalyzed Selective Reduction of Carboxylic Acids to Aldehydes

The direct reduction of carboxylic acids to aldehydes is a fundamental transformation in organic synthesis. The combination of an air-stable Ni precatalyst, dimethyl dicarbonate as an activator, and silane reductant effects this reduction for a wide variety of substrates, including pharmaceutically relevant structures, in good yields and with no overreduction to alcohols. Moreover, this methodology is scalable, allows access to deuterated aldehydes, and is also compatible with one-pot utilization of the aldehyde products.

Practical syntheses of a CXCR3 antagonist

Two new, reliable syntheses of a pyrido[2,3-d]- pyrimidine inhibitor of the CXCR3 receptor are described. A nine-step synthesis of the CXCR3 inhibitor (1) from 2-aminonicotinic acid was demonstrated on a multikilogram scale and incorporates a classic reso