494799-15-4

Basic information

• Product Name: 1H-Indole-6-carboxylic acid, 3-cyclohexyl-2-phenyl-
• CAS NO: 494799-15-4
• Molecular Formula: C21H21NO2
• Molecular Weight: 319.403
• Mol File: 494799-15-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1H-Indole-6-carboxylic acid, 3-cyclohexyl-2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-6-carboxylic acid, 3-cyclohexyl-2-phenyl-(494799-15-4)
• EPA Substance Registry System: 1H-Indole-6-carboxylic acid, 3-cyclohexyl-2-phenyl-(494799-15-4)

Safety Data

• Hazardous Substances Data: 494799-15-4(Hazardous Substances Data)

Usage

General Description

1H-Indole-6-carboxylic acid, 3-cyclohexyl-2-phenyl- is a chemical compound with a molecular structure containing a cyclohexyl and phenyl group attached to an indole ring. It is a derivative of indole-6-carboxylic acid and is often used in pharmaceutical research and drug development. 1H-Indole-6-carboxylic acid, 3-cyclohexyl-2-phenyl- has potential therapeutic applications due to its ability to interact with biological targets such as receptors and enzymes, making it a valuable tool for studying biological processes and developing new medications. Its specific properties and potential uses make it an important compound in the field of medicinal chemistry and drug discovery.

Upstream product

• 108-94-1 cyclohexanone 
• 50820-65-0 indole-6-carboxylic acid methyl ester 
• 494799-18-7 methyl 3-cyclohexyl-1H-indole-6-carboxylate 
• 494799-14-3 3-cyclohexyl-2-phenylindole-6-carboxylic acid methyl ester 
• 1670-82-2 Indole-6-carboxylic acid 
• 494799-19-8 methyl 2-bromo-3-cyclohexyl-1H-indole-6-carboxylate 
• 494799-16-5 3-(cyclohex-1-en-1-yl)-1H-indole-6-carboxylic acid 
• 494799-17-6 3-cyclohexyl-1-methyl-1H-indole-6-carboxylic acid 

Relevant articles and documents

Improved replicon cellular activity of non-nucleoside allosteric inhibitors of HCV NS5B polymerase: From benzimidazole to indole scaffolds

Benzimidazole-based allosteric inhibitors of the hepatitis C virus (HCV) NS5B polymerase were diversified to a variety of topologically related scaffolds. Replacement of the polar benzimidazole core by lipophilic indoles led to inhibitors with improved potency in the cell-based subgenomic HCV replicon system. Transposing the indole scaffold into a previously described series of benzimidazole-tryptophan amides generated the most potent inhibitors of HCV RNA replication in cell culture reported to date in this series (EC50 ～ 50 nM).

Development and preliminary optimization of indole-N-acetamide inhibitors of hepatitis C virus NS5B polymerase

Allosteric inhibition of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase enzyme has recently emerged as a viable strategy toward blocking replication of viral RNA in cell-based systems. We report here a novel class of allosteric inhibitor of NS5B that shows potent affinity for the NS5B enzyme and effective inhibition of subgenomic HCV RNA replication in HUH-7 cells. Inhibitors from this class have promising characteristics for further development as anti-HCV agents.

VIRAL POLYMERASE INHIBITORS

An isomer, enantiomer, diastereoisomer or tautomer of a compound, represented by formula (I): wherein wherein A, B, R2, R3, L, M1, M2, M3, M4, Y1, Y0, Z and Sp are as defined in claim 1, or a salt thereof, as an inhibitor of HCV NS5B polymerase.