494799-17-6 Usage
Description
3-Cyclohexylindole-6-carboxylic acid is an organic compound with a cyclohexyl group attached to an indole ring, featuring a carboxylic acid functional group at the 6th position. It is a key intermediate in the synthesis of various pharmaceutical compounds due to its unique structural properties and reactivity.
Uses
Used in Pharmaceutical Industry:
3-Cyclohexylindole-6-carboxylic acid is used as a reactant for the preparation of dibenzo[b,f][1,4]thiazepinecarboxamides, which are known as hepatitis B core protein modulators. These modulators play a crucial role in the development of treatments for hepatitis B, a viral infection that affects the liver and can lead to severe health complications.
The application of 3-cyclohexylindole-6-carboxylic acid in the pharmaceutical industry is primarily due to its ability to react with other molecules to form therapeutically relevant compounds. Its unique structure allows for the creation of novel drug candidates that can potentially target specific proteins or pathways involved in the progression of hepatitis B, offering new treatment options for patients suffering from this disease.
Check Digit Verification of cas no
The CAS Registry Mumber 494799-17-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,9,4,7,9 and 9 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 494799-17:
(8*4)+(7*9)+(6*4)+(5*7)+(4*9)+(3*9)+(2*1)+(1*7)=226
226 % 10 = 6
So 494799-17-6 is a valid CAS Registry Number.
InChI:InChI=1/C15H17NO2/c17-15(18)11-6-7-12-13(9-16-14(12)8-11)10-4-2-1-3-5-10/h6-10,16H,1-5H2,(H,17,18)
494799-17-6Relevant articles and documents
The First Kilogram Synthesis of Beclabuvir, an HCV NS5B Polymerase Inhibitor
Bien, Jeffrey,Davulcu, Akin,Delmonte, Albert J.,Fraunhoffer, Kenneth J.,Gao, Zhinong,Hang, Chao,Hsiao, Yi,Hu, Wenhao,Katipally, Kishta,Littke, Adam,Pedro, Aghogho,Qiu, Yuping,Sandoval, Maria,Schild, Richard,Soltani, Michelle,Tedesco, Anthony,Vanyo, Dale,Vemishetti, Purushotham,Waltermire, Robert E.
, p. 1393 - 1408 (2018/09/06)
The process development and kilogram-scale synthesis of beclabuvir (BMS-791325, 1) is described. The convergent synthesis features the use of asymmetric catalysis to generate a chiral cyclopropane fragment and coupling with an indole fragment via an alkyl
CARBOXYL SUBSTITUTED INDOLES FOR USE AS PPAR ALPHA MODULATORS
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Page/Page column 65-66, (2009/12/28)
There is provided according to the invention novel compounds of formula (I) or pharmaceutically acceptable salts or solvates thereof wherein one of R1 and R2 is H and the other is COOH. The compounds are useful as PPAR modulators.
Compounds for the Treatment of Hepatitis C
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, (2008/12/07)
The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.