494799-21-2

Basic information

• Product Name: 1H-Indole-6-carboxylicacid, 3-cyclohexyl-1-methyl-, methyl ester
• Synonyms: Methyl3-cyclohexyl-1-methyl-6-indolecarboxylate
• CAS NO: 494799-21-2
• Molecular Formula: C17H21 N O2
• Molecular Weight: 271.35400
• Mol File: 494799-21-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1H-Indole-6-carboxylicacid, 3-cyclohexyl-1-methyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-6-carboxylicacid, 3-cyclohexyl-1-methyl-, methyl ester(494799-21-2)
• EPA Substance Registry System: 1H-Indole-6-carboxylicacid, 3-cyclohexyl-1-methyl-, methyl ester(494799-21-2)

Safety Data

• Hazardous Substances Data: 494799-21-2(Hazardous Substances Data)

Upstream product

• 494799-18-7 methyl 3-cyclohexyl-1H-indole-6-carboxylate 
• 74-88-4 methyl iodide 
• 109-04-6 2-bromo-pyridine 
• 108-94-1 cyclohexanone 
• 1670-82-2 Indole-6-carboxylic acid 
• 494799-16-5 3-(cyclohex-1-en-1-yl)-1H-indole-6-carboxylic acid 
• 494799-17-6 3-cyclohexyl-1-methyl-1H-indole-6-carboxylic acid 

Downstream Products

• 494799-77-8 3-cyclohexyl-2-furan-3-yl-1-methyl-1H-indole-6-carboxylic acid 
• 494799-22-3 2-bromo-3-cyclohexyl-1-methylindole-6-carboxylic acid methyl ester 

Relevant articles and documents

Improved replicon cellular activity of non-nucleoside allosteric inhibitors of HCV NS5B polymerase: From benzimidazole to indole scaffolds

Benzimidazole-based allosteric inhibitors of the hepatitis C virus (HCV) NS5B polymerase were diversified to a variety of topologically related scaffolds. Replacement of the polar benzimidazole core by lipophilic indoles led to inhibitors with improved potency in the cell-based subgenomic HCV replicon system. Transposing the indole scaffold into a previously described series of benzimidazole-tryptophan amides generated the most potent inhibitors of HCV RNA replication in cell culture reported to date in this series (EC50 ～ 50 nM).