735287-38-4

Basic information

• Product Name: 1H-Indole-1-acetic acid, 2-bromo-3-cyclohexyl-6-(methoxycarbonyl)-
• CAS NO: 735287-38-4
• Molecular Formula: C18H20BrNO4
• Molecular Weight: 394.265
• Mol File: 735287-38-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1H-Indole-1-acetic acid, 2-bromo-3-cyclohexyl-6-(methoxycarbonyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-1-acetic acid, 2-bromo-3-cyclohexyl-6-(methoxycarbonyl)-(735287-38-4)
• EPA Substance Registry System: 1H-Indole-1-acetic acid, 2-bromo-3-cyclohexyl-6-(methoxycarbonyl)-(735287-38-4)

Safety Data

• Hazardous Substances Data: 735287-38-4(Hazardous Substances Data)

Upstream product

• 50820-65-0 indole-6-carboxylic acid methyl ester 
• 108-94-1 cyclohexanone 
• 494799-19-8 methyl 2-bromo-3-cyclohexyl-1H-indole-6-carboxylate 
• 494799-16-5 3-(cyclohex-1-en-1-yl)-1H-indole-6-carboxylic acid 
• 494799-17-6 3-cyclohexyl-1-methyl-1H-indole-6-carboxylic acid 
• 494799-18-7 methyl 3-cyclohexyl-1H-indole-6-carboxylate 
• 774213-79-5 methyl 2-bromo-1-(2-tert-butoxy-2-oxoethyl)-3-cyclohexyl-1H-indole-6-carboxylate 

Downstream Products

• 844893-00-1 2-(4-benzyloxy-phenyl)-3-cyclohexyl-1-dimethylcarbamoylmethyl-1H-indole-6-carboxylic acid methyl ester 
• 774211-87-9 3-cyclohexyl-1-[2-(dimethylamino)-2-oxoethyl]-2-(4-methoxyphenyl)-1H-indole-6-carboxylic acid 
• 861966-97-4 methyl 2-cyclohex-1-en-1-yl-3-cyclohexyl-1-{2-[4-(dimethylamino)piperidin-1-yl]-2-oxoethyl}-1H-indole-6-carboxylate 
• 861967-37-5 methyl 2,3-dicyclohexyl-1-{2-[4-(dimethylamino)piperidin-1-yl]-2-oxoethyl}-1H-indole-6-carboxylate 
• 861967-00-2 methyl 2-bromo-3-cyclohexyl-1-{2-[4-(dimethylamino)piperidin-1-yl]-2-oxoethyl}-1H-indole-6-carboxylate 
• 735287-01-1 methyl 2-bromo-3-cyclohexyl-1-[2-(dimethylamino)-2-oxoethyl]-1H-indole-6-carboxylate 
• 848485-51-8 2-bromo-3-cyclohexyl-1-(2-morpholin-4-yl-2-oxoethyl)-1H-indole-6-carboxylate 

Relevant articles and documents

Allosteric N-acetamide-indole-6-carboxylic acid thumb pocket 1 inhibitors of hepatitis C virus NS5B polymerase-Acylsulfonamides and acylsulfamides as carboxylic acid replacements

Acylsulfonamide and acylsulfamide as surrogates for the carboxylic acid function of N-acetamide-indole-6-carboxylic acids were evaluated as allosteric inhibitors of hepatitis C virus (HCV) NS5B polymerase. Several analogs displayed excellent antiviral pot

Development and preliminary optimization of indole-N-acetamide inhibitors of hepatitis C virus NS5B polymerase

Allosteric inhibition of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase enzyme has recently emerged as a viable strategy toward blocking replication of viral RNA in cell-based systems. We report here a novel class of allosteric inhibitor of NS5B that shows potent affinity for the NS5B enzyme and effective inhibition of subgenomic HCV RNA replication in HUH-7 cells. Inhibitors from this class have promising characteristics for further development as anti-HCV agents.