495414-06-7

Basic information

• Product Name: 4-Bromo-2-(bromomethyl)-1-iodobenzene
• Synonyms: 4-Bromo-2-(bromomethyl)-1-iodobenzene;5-Bromo-2-iodobenzyl bromide 95+%;5-bromo-2-iodobenzyl bromide
• CAS NO: 495414-06-7
• Molecular Formula: C₇H₅Br₂I
• Molecular Weight: 376
• Mol File: 495414-06-7.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Bromo-2-(bromomethyl)-1-iodobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-2-(bromomethyl)-1-iodobenzene(495414-06-7)
• EPA Substance Registry System: 4-Bromo-2-(bromomethyl)-1-iodobenzene(495414-06-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 495414-06-7(Hazardous Substances Data)

Usage

General Description

4-Bromo-2-(bromomethyl)-1-iodobenzene is a chemical compound known for its three halogen atoms attached to the phenyl ring — an iodine and two bromine atoms. Its molecular formula is C7H5Br2I, depicting seven carbon, five hydrogen, two bromine, and one iodine atoms in each molecule. It's commonly used as a building block, reagent, or intermediate in a variety of chemical reactions, often in the area of organic synthesis or pharmaceutical development. It's typically a solid substance at room temperature with important storage safety precautions due to its reactive halogen nature. Details about its exact physical and chemical properties, such as melting point, boiling point, density, and solubility, are determined mostly by empirical information and may vary slightly based on the conditions presented.

Upstream product

• 199786-58-8 (5-bromo-2-iodo-phenyl)-methanol 
• 21740-00-1 5-bromo-2-iodo-benzoic acid 
• 116632-39-4 2-methyl-4-bromoiodobenzene 

Downstream Products

• 495414-05-6 3-(5-bromo-2-iodophenyl)-2,2-dimethylpropanenitrile 
• 10489-28-8 2,2-dimethyl-indan-1-one 
• 495414-32-9 5-bromo-2,2-dimethyl-2,3-dihydro-1H-inden-1-one 
• 1055901-15-9 2-(5-bromo-2-iodophenyl)acetonitrile 
• 864749-97-3 N-(4-chloro-2-vinyl-phenyl)-N-(2,5-dibromo-benzyl)-acetamide 
• 1178576-94-7 2-benzenesulfonylmethyl-4-bromo-1-iodo-benzene 
• 1278522-46-5 (Z)-1,2-bis(5-bromo-2-iodophenyl)ethene 
• 1279129-78-0 (5-bromo-2-iodobenzyl)triphenylphosphonium bromide 
• 1279129-98-4 2,8-bis(trimethylsilylethynyl)-5-(2,4,6-tri-tert-butylphenyl)dibenzo[b,f]borepin 
• 1279129-99-5 3,7-bis(trimethylsilylethynyl)-5-(2,4,6-tri-tert-butylphenyl)dibenzo[b,f]borepin 
• 1279129-81-5 2,8-diethynyl-5-(2,4,6-tri-tert-butylphenyl)dibenzo[b,f]borepin 
• 1279129-83-7 3,7-diethynyl-5-(2,4,6-tri-tert-butylphenyl)dibenzo[b,f]borepin 
• 1279129-77-9 2,8-dibromo-5-(2,4,6-tri-tert-butylphenyl)dibenzo[b,f]borepin 
• 1279129-80-4 2,8-di(thiophen-2-yl)-5-(2,4,6-tri-tert-butylphenyl)dibenzo[b,f]borepin 

Relevant articles and documents

Pd(II)-Catalyzed Synthesis of Benzocyclobutenes by β-Methylene-Selective C(sp3)-H Arylation with a Transient Directing Group

Methylene-selective C-H functionalization is a significant hurdle that remains to be addressed in the field of Pd(II) catalysis. We report a Pd(II)-catalyzed synthesis of benzocyclobutenes by methylene-selective C(sp3)-H arylation of ketones. The reaction utilizes glycine as a transient directing group and a 2-pyridone ligand, which may govern the methylene selectivity by making intimate molecular associations with the substrate during concerted metalation-deprotonation. This reaction is shown to be highly selective for intramolecular methylene C(sp3)-H arylation, thus enabling sequential C(sp3)-H functionalization.

CuSO4-Catalyzed Tandem C(sp3)-H Insertion Cyclization of Toluenes with Isonitriles to Form Indoles

A CuSO4-catalyzed tandem benzylic C-H insertion cyclization of toluene derivatives and isonitriles is described. The naturally abundant salt CuSO4 serves as a low-cost ligand-free redox catalyst. This reaction provides a practical mo

2-METHYL-QUINAZOLINES

The present invention describes 2-methyl-quinazoline compounds of general formula (I), methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions. The 2-methyl substituted quinazoline compounds of general formula(I) effectively and selectively inhibit the Ras-Sos interaction without significantly targeting the EGFR receptor. They are therefore useful for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, such as cancer as a sole agent or in combination with other active ingredients.