495414-32-9

Basic information

• Product Name: 5-BROMO-2,3-DIHYDRO-2,2-DIMETHYL-1H-INDEN-1-ONE
• Synonyms: 5-BROMO-2,3-DIHYDRO-2,2-DIMETHYL-1H-INDEN-1-ONE;5-bromo-2,2-dimethyl-3H-inden-1-one
• CAS NO: 495414-32-9
• Molecular Formula: C₁₁H₁₁BrO
• Molecular Weight: 239.11
• Mol File: 495414-32-9.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-BROMO-2,3-DIHYDRO-2,2-DIMETHYL-1H-INDEN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-2,3-DIHYDRO-2,2-DIMETHYL-1H-INDEN-1-ONE(495414-32-9)
• EPA Substance Registry System: 5-BROMO-2,3-DIHYDRO-2,2-DIMETHYL-1H-INDEN-1-ONE(495414-32-9)

Safety Data

• Hazardous Substances Data: 495414-32-9(Hazardous Substances Data)

Usage

Description

5-BROMO-2,3-DIHYDRO-2,2-DIMETHYL-1H-INDEN-1-ONE is an organic compound with the molecular formula C11H13BrO. It is a derivative of indenone, featuring a bromo substituent at the 5-position, and two methyl groups at the 2-position. 5-BROMO-2,3-DIHYDRO-2,2-DIMETHYL-1H-INDEN-1-ONE is known for its potential applications in the pharmaceutical and chemical industries due to its unique structural properties.

Uses

Used in Pharmaceutical Industry:
5-BROMO-2,3-DIHYDRO-2,2-DIMETHYL-1H-INDEN-1-ONE is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structural features make it a valuable building block for the development of new drugs with potential therapeutic applications.
Used in the Preparation of GPR35 Modulators:
5-BROMO-2,3-DIHYDRO-2,2-DIMETHYL-1H-INDEN-1-ONE is used as a starting material in the preparation of substituted Triazolopyrimidines, which are known as GPR35 modulators. GPR35 is a G-protein coupled receptor that has been implicated in various physiological processes and diseases. Modulating the activity of GPR35 can potentially lead to the development of new treatments for conditions such as cancer, inflammation, and metabolic disorders.

Upstream product

• 495414-05-6 3-(5-bromo-2-iodophenyl)-2,2-dimethylpropanenitrile 
• 34598-49-7 5-Bromo-1-indanone 
• 74-88-4 methyl iodide 
• 926625-06-1 3-(3-bromophenyl)-2,2-dimethylpropionic acid 
• 926625-05-0 methyl 3-(3-bromophenyl)-2,2-dimethylpropionate 
• 591-17-3 meta-bromotoluene 
• 823-78-9 meta-bromobenzyl bromide 
• 495414-06-7 4-bromo-2-(bromomethyl)-1-iodobenzene 
• 21740-00-1 5-bromo-2-iodo-benzoic acid 
• 199786-58-8 (5-bromo-2-iodo-phenyl)-methanol 

Downstream Products

• 918335-60-1 N-Cyclopropyl-3-(2,2-dimethyl-1-oxoindan-5-ylamino)-4-fluorobenzamide 
• 1356698-33-3 5-(3-methoxyphenyl)-2,2-dimethylindan-1-one 
• 1356698-29-7 5-(4-methoxyphenyl)-2,2-dimethylindan-1-one 
• 1356698-35-5 5-(4-hydroxyphenyl)-2,2-dimethylindan-1-one 
• 1356698-36-6 5-(3-hydroxyphenyl)-2,2-dimethylindan-1-one 
• 1356058-73-5 1-but-3-en-1-yl-5-(4-hydroxyphenyl)-2,2-dimethylindan-1-ol 
• 1356698-37-7 1-but-3-en-1-yl-5-(3-hydroxyphenyl)-2,2-dimethylindan-1-ol 
• 1356698-38-8 1-(4-hydroxybutyl)-5-(4-hydroxyphenyl)-2,2-dimethylindan-1-ol 
• 1356059-25-0 1-(4-hydroxybutyl)-5-(3-hydroxyphenyl)-2,2-dimethylindan-1-ol 
• 1356058-41-7 5-(4-hydroxyphenyl)-2,2-dimethyl-2,3,4',5'-tetrahydrospiro[indene-1,2'-pyran]-6'(3'H)-one 
• 1356058-95-1 5-(3-hydroxyphenyl)-2,2-dimethyl-2,3,4',5'-tetrahydrospiro[indene-1,2'-pyran]-6'(3'H)-one 

Relevant articles and documents

FERROPTOSIS INHIBITORS–DIARYLAMINE PARA-ACETAMIDES

Provided are compounds that inhibit ferroptosis activity, or modulate or inhibit a disease associated with ferroptosis dysregulation, such as neuropathy, ischemia reperfusion injury, acute kidney failure and cancer, including corresponding sulfonamides, and pharmaceutically acceptable salts, hydrates and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.

Silylative Kinetic Resolution of Racemic 2,2-Dialkyl 5- and 6-Membered Cyclic Benzylic Alcohol Derivatives Catalyzed by Chiral Guanidine, (R)-N-Methylbenzoguanidine

Efficient silylative kinetic resolution of racemic 2,2-dialkyl 5- and 6-membered cyclic benzylic alcohols was achieved using diphenylmethylchlorosilane (Ph2MeSiCl) or phenyldimethylchlorosilane (PhMe2SiCl) as a silyl source catalyzed by chiral guanidine. The reaction could be applied to a broad range of 2,2-dialkyl 1-indanols with good s-values, irrespective of the electronic nature of the substituent on the aromatic ring of the substrates and the type of substituent at the C2-position. In addition, several 2,2-dimethyl 6-membered cyclic and heterocyclic alcohols could be adopted in the reaction. (Figure presented.).

CYCLOALKYL NITRILE PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS

Compounds of formula I are provided, which are JAK inhibitors and are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.