49568-76-5

Basic information

• Product Name: 2(1H)-Quinoxalinone, 3-benzoyl-
• CAS NO: 49568-76-5
• Molecular Formula: C15H10N2O2
• Molecular Weight: 250.257
• Mol File: 49568-76-5.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: 2(1H)-Quinoxalinone, 3-benzoyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Quinoxalinone, 3-benzoyl-(49568-76-5)
• EPA Substance Registry System: 2(1H)-Quinoxalinone, 3-benzoyl-(49568-76-5)

Safety Data

• Hazardous Substances Data: 49568-76-5(Hazardous Substances Data)

Upstream product

• 24949-43-7 3-benzylquinoxalin-2-one 
• 6476-17-1 ethyl 3-bromo-2-oxo-3-phenylpropionate 
• 1196-57-2 quinoxalin-2⁽¹⁾-one 
• 100-52-7 benzaldehyde 
• 6125-26-4 phenyl(2-phenyl-2,3-dihydrobenzo[d]thiazol-2-yl)methanone 
• 611-73-4 Benzoylformic acid 
• 156-06-9 2-oxo-3-(phenyl)propionic acid 
• 95-54-5 1,2-diamino-benzene 
• 289704-35-4 2-oxo-3-(α-thiocyanobenzyl)-1,2-dihydroquinoxaline 
• 124831-91-0 3-(α-chlorobenzyl)-1,2-dihydroxyquinoxalin-2-one 
• 881-90-3 4-benzylidene-2-methyl-2-oxazolin-5-one 
• 24949-43-7 3-benzylquinoxalin-2-ol 
• 16439-95-5 4-phenyl-2,3-dihydro-1H-1,5-benzodiazepin-2-one 
• 6323-89-3 3-[2-phenylethenyl]quinoxalin-2(1H)-one 

Downstream Products

• 49568-79-8 (3-chloroquinoxalin-2-yl)(phenyl)methanone 

Relevant articles and documents

The kornblum reaction of α-substituted 3-benzyl-1,2-dihydro-2-oxoquinoxalines. Synthesis and structure of 3-benzoyl-2-oxo-1,2-dihydroquinoxaline

A method has been developed for the preparation of 3-benzoyl-2-oxo-1,2-dihydroquinoxaline by the reaction of 3-(α-chlorobenzyl)-1,2-dihydroquinoxaline under Kornblum reaction conditions to the corresponding α-azido derivative and then acid fission of the latter. The structure of the target ketone has been confirmed by x-ray analysis.

Oxidative dehydrobromination of 3-(α-bromobenzyl)quinoxalin-2(1H)- ones according to Kornblum as a simple and efficient synthetic route to quinoxalyl aryl ketones

Condensation of ethyl 3-aryl-3-bromo-2-oxopropanoates with o-phenylenediamine in acetic acid gave 3-(α-bromobenzyl)quinoxalin-2(1H)- ones which were converted in high yield into the corresponding 3-aroylquinoxalin-2(1H)-ones via oxidative dehydrobrominati

Intramolecular oxidative rearrangement: I2/TBHP/DMSO-mediated metal free facile access to quinoxalinone derivatives

Iodine/TBHP/DMSO mediated oxidative rearrangement of 3-styrylquinoxalin-2(1H)-one led to the formation of 3-aroylquinoxalin-2(1H)-ones in good to high yields via Kornblum oxidation. This methodology proceeds under mild conditions via oxidative aryl migrat

Preparation method 3 -acyl quinoxalinone derivatives

The invention discloses a method for preparing a 3-acyl quinoxaline ketone derivative (I) and belongs to the field of organic chemistry The method comprises the following steps: by taking a substituted quinoxaline-2-ketone derivative and aldehyde or benzyl alcohol as raw materials, and a 70% tert-butyl hydroperoxide (TBHP) solution as an oxidant, performing a heating reaction in a solvent withoutmetal catalysis, thereby synthesizing the 3-acyl quinoxaline ketone derivative. Compared with a conventional synthesis method, the method has the advantages that firstly, the raw materials are cheap and easy to obtain, the 3-acyl quinoxaline ketone derivative is synthesized at one step, the cost is low, and good application prospects can be achieved; secondly, the method is gentle in reaction condition, high in yield, convenient to operate, beneficial to industrial production and the like, and the reactions are carried out under an air condition. The derivative has potential application in fields such as medicines, chemical engineering and materials, and the invention provides a novel way for synthesis of 3-acyl quinoxaline ketone derivatives. (Refer to Specification).