49579-56-8

Basic information

• Product Name: 2-ACETAMIDO-5-FLUOROBENZOIC ACID
• Synonyms: N-ACETYL-5-FLUOROANTHRANILIC ACID;BUTTPARK 19\04-55;2-ACETAMIDO-5-FLUOROBENZOIC ACID;2-ACETAMIDO-5-FLUOROBENZOIC ACID 98%;N-Acetyl-5-fluoroanthranilic acid, 2-(Acetylamino)-5-fluorobenzoic acid, 2'-Carboxy-4'-fluoroacetanilide
• CAS NO: 49579-56-8
• Molecular Formula: C₉H₈FNO₃
• Molecular Weight: 197.16
• Mol File: 49579-56-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 413.8 °C at 760 mmHg
• Flash Point: 204 °C
• Appearance: /
• Density: 1.415 g/cm³
• Vapor Pressure: 1.38E-07mmHg at 25°C
• Refractive Index: 1.597
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-ACETAMIDO-5-FLUOROBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ACETAMIDO-5-FLUOROBENZOIC ACID(49579-56-8)
• EPA Substance Registry System: 2-ACETAMIDO-5-FLUOROBENZOIC ACID(49579-56-8)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• Hazardous Substances Data: 49579-56-8(Hazardous Substances Data)

Usage

General Description

2-ACETAMIDO-5-FLUOROBENZOIC ACID is a chemical compound with the molecular formula C9H8FNO3. It is a white solid with a molecular weight of 191.16 g/mol. 2-ACETAMIDO-5-FLUOROBENZOIC ACID is commonly used in the pharmaceutical industry as an intermediate in the synthesis of various drugs, particularly as an intermediate in the production of anti-inflammatory and analgesic drugs. Its chemical structure consists of a benzoic acid core with an acetamido group and a fluorine atom attached to the benzene ring. 2-ACETAMIDO-5-FLUOROBENZOIC ACID is known for its potential pharmaceutical applications and is regulated for its safe handling and storage due to its potential health hazards.

InChI:InChI=1/C9H8FNO3/c1-5(12)11-8-3-2-6(10)4-7(8)9(13)14/h2-4H,1H3,(H,11,12)(H,13,14)

Upstream product

• 326-65-8 N-(4-fluoro-2-methylphenyl)acetamide 
• 446-08-2 2-amino-5-fluorobenzoic acid 
• 32833-96-8 N,N-dimethyloxamic acid 
• 351-83-7 4'-fluoroacetanilide 

Downstream Products

• 446-08-2 2-amino-5-fluorobenzoic acid 
• 49579-12-6 3-(2-chloro-phenyl)-6-fluoro-2-methyl-3H-quinazolin-4-one 
• 291276-26-1 3-(2-chloro-phenyl)-6-fluoro-2-[2-(2-fluoro-phenyl)-2-hydroxy-vinyl]-3H-quinazolin-4-one 
• 56096-92-5 2-(4-Chlorphenylthio)-5-fluorbenzylalkohol 
• 56096-94-7 2-(4-Chlorphenylthio)-5-fluorbenzylchlorid 
• 56096-90-3 2-(4-Chlorphenylthio)-5-fluorbenzoesaeure 
• 56096-96-9 [2-(4-Chloro-phenylsulfanyl)-5-fluoro-phenyl]-acetonitrile 
• 56096-98-1 [2-(4-Chloro-phenylsulfanyl)-5-fluoro-phenyl]-acetic acid 
• 52548-63-7 5-fluoro-2-iodobenzoic acid 
• 1353623-02-5 C₂₂H₂₄FN₅O₃ 

Relevant articles and documents

De Novo Biosynthesis and Whole-Cell Catalytic Production of 2-Acetamidophenol in Escherichia coli

2-Acetamidophenol (AAP) is an aromatic product with promising activities in agricultural applications and medical research. At present, AAP is synthesized by chemical methods from nonrenewable fossil fuel resources, which cause environmental pollution and the reaction conditions are harsh. In this study, we constructed the artificial biosynthetic pathway of AAP with five different expressed proteins in Escherichia coli for the first time. By introducing the hydrogen peroxide degrading enzyme catalase and improving cell tolerance to toxic intermediates or products, the yield of AAP reached 33.54 mg/L using shaking-flask culture. The best-engineered strain could produce 568.57 mg/L AAP by fed-batch fermentation from glucose and precursor (2-aminophenol, 2-AP) addition. Furthermore, a one-pot whole-cell cascade biocatalytic pathway to AAP and analogues was developed and optimized. This method can efficiently produce 1.8 g/L AAP using the methyl anthranilate hydrolysis product as the substrate. This study provides not only the de novo artificial biosynthetic pathway of AAP in E. coli but also a promising sustainable and efficient strategy to enable the synthesis of AAP on a gram scale.

Amino-benzoic acids and derivatives, and methods of use

The present invention relates to compounds, compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with a carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.