52548-63-7

Basic information

• Product Name: 5-Fluoro-2-iodobenzoic acid
• Synonyms: 5-Fluoro-2-iodobenzoic acid
• CAS NO: 52548-63-7
• Molecular Formula: C₇H₄FIO₂
• Molecular Weight: 266.01
• Product Categories: API intermediates;C7;Carbonyl Compounds;Carboxylic Acids;Fluorine series
• Mol File: 52548-63-7.mol
• Article Data: 13

Chemical Properties

• Melting Point: 145-149 °C
• Boiling Point: 307.896 °C at 760 mmHg
• Flash Point: 140.01 °C
• Appearance: /
• Density: 2.074 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.638
• Storage Temp.: 2-8°C(protect from light)
• Solubility: soluble in Methanol
• PKA: 2.52±0.10(Predicted)
• Sensitive: Light Sensitive
• CAS DataBase Reference: 5-Fluoro-2-iodobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Fluoro-2-iodobenzoic acid(52548-63-7)
• EPA Substance Registry System: 5-Fluoro-2-iodobenzoic acid(52548-63-7)

Safety Data

• Hazard Codes: T
• Statements: 25-36/37/38
• Safety Statements: 26-45
• RIDADR: UN 2811
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: Ⅲ
• Hazardous Substances Data: 52548-63-7(Hazardous Substances Data)

Usage

General Description

5-Fluoro-2-iodobenzoic acid is a specialty chemical falling under the category of organic compounds. It contains one carbon, one hydrogen, one iodine, one fluorine, and two oxygen atoms. Known for its high level of purity, it is often utilized in various areas of chemistry, such as organic synthesis, pharmaceutical drug discovery, and materials science. Additionally, due to its reactive potential, it is often used to create more complex chemical molecules via component reactions. It's necessary to handle this chemical with care due to its potentially toxic and harmful effects.

InChI:InChI=1/C7H4FIO2/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3H,(H,10,11)

Upstream product

• 446-08-2 2-amino-5-fluorobenzoic acid 
• 326-65-8 N-(4-fluoro-2-methylphenyl)acetamide 
• 49579-56-8 2-acetamido-5-fluorobenzoic acid 
• 52548-59-1 10-chloro-2-fluoro-10,11-dihydro-dibenzo[b,f]thiepine 
• 52548-62-6 2-amino-5-fluorobenzoic acid hydrochloride 
• 110-16-7 maleic acid 

Downstream Products

• 56096-90-3 2-(4-Chlorphenylthio)-5-fluorbenzoesaeure 
• 82341-39-7 2-(4-Ethoxycarbonyl-phenoxy)-5-fluoro-benzoic acid 
• 91527-94-5 5-fluoro-2-(4-isopropylphenylthio)benzoic acid 
• 134987-41-0 5-fluoro-2-(3-methoxyphenylthio)benzoic acid 
• 52548-64-8 5-fluoro-2-(phenylthio)benzoic acid 
• 82340-88-3 [2-(4-Cyanomethyl-phenoxy)-5-fluoro-phenyl]-acetonitrile 
• 82340-94-1 [2-(4-Carboxymethyl-phenoxy)-5-fluoro-phenyl]-acetic acid 
• 91528-00-6 5-fluoro-2-(4-isopropylphenylthio)benzyl chloride 
• 91527-97-8 5-fluoro-2-(4-isopropylphenylthio)benzyl alcohol 
• 91528-03-9 5-fluoro-2-(4-isopropylphenylthio)phenylacetonitril 
• 91528-10-8 2-fluoro-8-isopropyldibenzothiepin-10(11H)-one 
• 91528-05-1 2-<5-fluoro-2-(4-isopropylphenylthio)phenyl>acetic acid 
• 91528-28-8 1-(2-Fluoro-8-isopropyl-10,11-dihydro-dibenzo[b,f]thiepin-10-yl)-4-methyl-piperazine; compound with methanesulfonic acid 
• 91528-22-2 2-fluoro-8-isopropyl-10-(4-methylpiperazino)-10,11-dihydrodibenzothiepin 

Relevant articles and documents

Preparation method of lorlatinib intermediate compound

The invention relates to a preparation method of a lorlatinib intermediate compound. 4-fluoroacetanilide is taken as a raw material and carry out visible light Fries rearrangement in the presence of avisible light catalyst and visible light to obtain an i

Copper-Catalyzed C(sp3)-S Bond and C(sp2)-S Bond Cross-Coupling of 2-(2-Iodobenzoyl) Substituted or 2-(2-Iodobenzyl) Substituted 1,2,3,4-Tetrahydroisoquinolines with Potassium Sulfide: Synthesis of Isoquinoline-Fused 1,3-Benzothiazine Scaffolds

The sulfuration reaction of 2-(2-iodobenzoyl) substituted, or 2-(2-iodobenzyl) substituted 1,2,3,4-tetrahydroisoquinolines with potassium sulfide proceeded in the presence of copper catalysts to give tetrahydroisoquinoline-fused 1,3-benzothiazine scaffolds in moderate to appropriate yields. This protocol provided an efficient and simple strategy to construct the corresponding benzothiazine derivatives via formation of C(sp3)-S bond and C(sp2)-S bond, which the C-S bonds formed via different routes in this reaction (traditional cross-coupling reaction via the cleavage of C-I bond and oxidative cross-coupling reaction via C(sp3)-H bond functionalization).

Lewis Acid Catalyzed Formal Intramolecular [3 + 3] Cross-Cycloaddition of Cyclopropane 1,1-Diesters for Construction of Benzobicyclo[2.2.2]octane Skeletons

A novel Lewis acid catalyzed formal intramolecular [3 + 3] cross-cycloaddition (IMCC) of cyclopropane 1,1-diesters has been successfully developed. This supplies an efficient and conceptually new strategy for construction of bridged bicyclo[2.2.2]octane skeletons. This [3 + 3]IMCC could be run up to gram scale and from easily prepared starting materials. This [3 + 3]IMCC, together with our previously reported [3 + 2]IMCC strategy, can afford either the bicyclo[2.2.2]octane or bicyclo[3.2.1]octane skeletons from the similar starting materials by regulating the substituents on vinyl group.