52548-64-8

Basic information

• Product Name: 5-fluoro-2-(phenylthio)benzoic acid
• Synonyms: 5-fluoro-2-(phenylthio)benzoic acid
• CAS NO: 52548-64-8
• Molecular Weight: 248.278
• Mol File: 52548-64-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-fluoro-2-(phenylthio)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-fluoro-2-(phenylthio)benzoic acid(52548-64-8)
• EPA Substance Registry System: 5-fluoro-2-(phenylthio)benzoic acid(52548-64-8)

Safety Data

• Hazardous Substances Data: 52548-64-8(Hazardous Substances Data)

Upstream product

• 394-28-5 2-Bromo-5-fluorobenzoic acid 
• 108-98-5 thiophenol 
• 52548-63-7 5-fluoro-2-iodobenzoic acid 
• 12775-96-1 copper 
• 52548-62-6 2-amino-5-fluorobenzoic acid hydrochloride 

Downstream Products

• 52548-65-9 3-fluoro-6-(phenylthio)-benzyl alcohol 
• 52548-68-2 3-fluoro-6-(phenylthio)-phenylacetic acid 
• 52548-67-1 3-fluoro-6-(phenylthio)-phenylacetonitrile 
• 52548-66-0 3-fluoro-6-(phenylthio)-benzyl chloride 

Relevant articles and documents

Carboxyl radical-assisted 1,5-aryl migration through Smiles rearrangement

We report herein, a silver(i)-catalyzed Smiles rearrangement of 2-aryloxy- or 2-(arylthio)benzoic acids to provide aryl-2-hydroxybenzoate or aryl-2-mercaptobenzoate dimer, respectively, through 1,5-aryl migration from oxygen or sulfur to carboxylate oxygen. Mechanistically, the aryl ether moiety undergoes an intramolecular ipso attack by the carboxyl radical followed by a C-O or C-S bond cleavage. Aryl-2-mercaptobenzoates undergo oxidative dimerization through a thiol moiety in situ.

Noncataleptic potential neuroleptics; 2 halogeno 10 piperazinodibenzo[b,f]thiepsins

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